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https://hdl.handle.net/1822/81962
Título: | Emerging antimicrobial and immunomodulatory fiber‐based scaffolding systems for treating diabetic foot ulcers |
Autor(es): | Felgueiras, Helena Prado |
Palavras-chave: | Diabetes Chronic wounds Fiber‐based scaffolds Bioactive agents Antimicrobial and immunomodulatory functions Improved wound healing |
Data: | 12-Jan-2023 |
Editora: | MDPI |
Revista: | Pharmaceutics |
Citação: | Felgueiras, H.P. Emerging Antimicrobial and Immunomodulatory Fiber-Based Scaffolding Systems for Treating Diabetic Foot Ulcers. Pharmaceutics 2023, 15, 258. https://doi.org/10.3390/pharmaceutics15010258 |
Resumo(s): | Diabetic foot ulcers (DFUs) are one of the main complications of diabetes and are characterized by their complexity and severity, which are frequently aggravated by overexpressed inflammatory factors and polymicrobial infections. Most dressing systems offer a passive action in the treatment of DFUs, being frequently combined with antibiotic or immunomodulatory therapies. However, in many instances due to these combined therapiesʹ inability to properly fight microbial presence, and provide a suitable, breathable and moist environment that is also capable of protecting the site from secondary microbial invasions or further harm, aggravation of the wound state is unavoidable and lower limb amputations are necessary. Considering these limitations and knowing of the urgent demand for new and more effective therapeutic systems for DFU care that will guarantee the quality of life for patients, research in this field has boomed in the last few years. In this review, the emerging innovations in DFU dressing systems via fiber‐based scaffolds modified with bioactive compounds have been compiled; data focused on the innovations introduced in the last five years (2017–2022). A generalized overview of the classifications and constraints associated with DFUs healing and the bioactive agents, both antimicrobial and immunomodulatory, that can contribute actively to surpass such issues, has also been provided. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/81962 |
DOI: | 10.3390/pharmaceutics15010258 |
e-ISSN: | 1999-4923 |
Versão da editora: | https://www.mdpi.com/1999-4923/15/1/258 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DET/2C2T - Artigos em revistas internacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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pharmaceutics-15-00258.pdf | 741,02 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons