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https://hdl.handle.net/1822/83196
Título: | Designing and characterization of curcumin-loaded nanotechnological dressings: a promising platform for skin burn treatment |
Autor(es): | Araújo, Gabriela de Moraes Soares Loureiro, Ana Isabel Sá Rodrigues, Jamile Lima Yurgel, Virginia Campello Silva, C. Cavaco-Paulo, Artur Dora, Cristiana Lima |
Palavras-chave: | Nanoemulsions Curcumin Gauze Burns |
Data: | 25-Mar-2023 |
Editora: | Elsevier |
Revista: | International Journal of Pharmaceutics |
Citação: | Araújo, Gabriela de Moraes Soares; Loureiro, Ana; Rodrigues, Jamile Lima; Yurgel, Virginia Campello; Silva, Carla; Cavaco-Paulo, Artur; Dora, Cristiana Lima, Designing and characterization of curcumin-loaded nanotechnological dressings: a promising platform for skin burn treatment. International Journal of Pharmaceutics, 635(122712), 2023 |
Resumo(s): | Burns affect the skin and appendages, impair their function, and become favorable regions for bacterial infections. Owing to time-consuming and costly treatments, burns have been considered a public health problem. The limitations of the treatments used for burns have motivated the search for more efficient alternatives. Curcumin has several potential properties such as anti-inflammatory, healing, and antimicrobial activities. However, this compound is unstable and has low bioavailability. Therefore, nanotechnology could offer a solution for its application. This study aimed to develop and characterize dressings (or gauzes) impregnated with curcumin nanoemulsions that were prepared using two different techniques as a promising platform for skin burn treatment. In addition, the effect of cationization on curcumin release from the gauze was evaluated. Nanoemulsions were successfully prepared using two methods, ultrasound and a high-pressure homogenizer, with sizes of 135 nm and 144.55 nm, respectively. These nanoemulsions exhibited a low polydispersity index, adequate zeta potential, high encapsulation efficiency, and stability for up to 120 d. In vitro assays demonstrated a controlled release of curcumin between 2 and 240 h. No cytotoxicity was observed at concentrations of curcumin up to 75 µg/mL, and cell proliferation was observed. The incorporation of nanoemulsions in the gauze was successfully achieved, and the evaluation of curcumin release showed a faster release from cationized gauzes, whereas the non-cationized gauze promoted a more constant release. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/83196 |
DOI: | 10.1016/j.ijpharm.2023.122712 |
ISSN: | 0378-5173 |
Versão da editora: | https://www.sciencedirect.com/science/article/abs/pii/S0378517323001321 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_56079_1.pdf Acesso restrito! | 991,85 kB | Adobe PDF | Ver/Abrir |