Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/83996

TítuloStarch-based films doped with porphyrinoid photosensitizers for active skin wound healing
Autor(es)Lopes, Paloma
Joaquinito, A. Sofia M.
Ribeiro, Artur
Moura, Nuno M. M.
Gomes, Ana T. P.
Guerreiro, Susana G.
Faustino, M. Amparo F.
Almeida, Adelaide
Ferreira, Paula
Coimbra, Manuel A.
Neves, M. Graça P. M. S.
Gonçalves, Idalina
Palavras-chavePolysaccharides
Porphyrins
Hydrophobicity
Elasticity
Antimicrobial
Cellular migration
DataAgo-2023
EditoraElsevier
RevistaCarbohydrate Polymers
CitaçãoLopes, P., Joaquinito, A. S. M., Ribeiro, A., Moura, N. M. M., Gomes, A. T. P., Guerreiro, S. G., … Gonçalves, I. (2023, August). Starch-based films doped with porphyrinoid photosensitizers for active skin wound healing. Carbohydrate Polymers. Elsevier BV. http://doi.org/10.1016/j.carbpol.2023.120894
Resumo(s)Starch is a biodegradable and biocompatible carbohydrate that, when combined with bioactive molecules, can be processed as biomimetic platforms with enhanced performance, allowing its use as active wound dressing materials. Porphyrinoid photosensitizers can tune the physicochemical/functional profile of biomacromolecules, allowing their use in anti-infective strategies. In this work, the feasibility of using the cationic 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin tetraiodide (TMPyP) to enhance the physicochemical, mechanical, antimicrobial performance, and wound healing ability of casted starch-based films was studied. TMPyP conferred a reddish coloration to the films, maintaining their pristine transparency. It increased by 87 % the films hydrophobicity and, depending on the TMPyP used, conferred mobility to the starch polymeric chains. Starch/TMPyP-based films effectively photoinactivated Escherichia coli (>99.99 %) and favored the wound healing process, even in the absence of light. Therefore, the incorporation of TMPyP into starch-based formulations revealed to be a promising strategy to tune the films compaction degree while giving rise to water tolerant and photosensitive biomaterials that can act as multitarget antimicrobial medical dressings and glycocarriers of active compounds relevant for effective skin wound healing.
TipoArtigo
URIhttps://hdl.handle.net/1822/83996
DOI10.1016/j.carbpol.2023.120894
ISSN0144-8617
Versão da editorahttp://www.journals.elsevier.com/carbohydrate-polymers/
Arbitragem científicayes
AcessoAcesso aberto
Aparece nas coleções:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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