Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/83996
Título: | Starch-based films doped with porphyrinoid photosensitizers for active skin wound healing |
Autor(es): | Lopes, Paloma Joaquinito, A. Sofia M. Ribeiro, Artur Moura, Nuno M. M. Gomes, Ana T. P. Guerreiro, Susana G. Faustino, M. Amparo F. Almeida, Adelaide Ferreira, Paula Coimbra, Manuel A. Neves, M. Graça P. M. S. Gonçalves, Idalina |
Palavras-chave: | Polysaccharides Porphyrins Hydrophobicity Elasticity Antimicrobial Cellular migration |
Data: | Ago-2023 |
Editora: | Elsevier |
Revista: | Carbohydrate Polymers |
Citação: | Lopes, P., Joaquinito, A. S. M., Ribeiro, A., Moura, N. M. M., Gomes, A. T. P., Guerreiro, S. G., … Gonçalves, I. (2023, August). Starch-based films doped with porphyrinoid photosensitizers for active skin wound healing. Carbohydrate Polymers. Elsevier BV. http://doi.org/10.1016/j.carbpol.2023.120894 |
Resumo(s): | Starch is a biodegradable and biocompatible carbohydrate that, when combined with bioactive molecules, can be processed as biomimetic platforms with enhanced performance, allowing its use as active wound dressing materials. Porphyrinoid photosensitizers can tune the physicochemical/functional profile of biomacromolecules, allowing their use in anti-infective strategies. In this work, the feasibility of using the cationic 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin tetraiodide (TMPyP) to enhance the physicochemical, mechanical, antimicrobial performance, and wound healing ability of casted starch-based films was studied. TMPyP conferred a reddish coloration to the films, maintaining their pristine transparency. It increased by 87 % the films hydrophobicity and, depending on the TMPyP used, conferred mobility to the starch polymeric chains. Starch/TMPyP-based films effectively photoinactivated Escherichia coli (>99.99 %) and favored the wound healing process, even in the absence of light. Therefore, the incorporation of TMPyP into starch-based formulations revealed to be a promising strategy to tune the films compaction degree while giving rise to water tolerant and photosensitive biomaterials that can act as multitarget antimicrobial medical dressings and glycocarriers of active compounds relevant for effective skin wound healing. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/83996 |
DOI: | 10.1016/j.carbpol.2023.120894 |
ISSN: | 0144-8617 |
Versão da editora: | http://www.journals.elsevier.com/carbohydrate-polymers/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_56207_1.pdf | 3,42 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons