Instituto de Investigação em Ciências da Vida e da Saúde : [3058] Estatísticas
Research lines developed by the 3 Research Domains of the ICVS, Infectious Diseases , Neurosciences and Development & Neoplasia :
A – Infectious Diseases
• The study of the neurodegenerative disorder Batten disease
• Human genetic factors predisposing susceptibility to invasive fungal infections
• Identification of clinically relevant fungi causing systemic mycosis
• Cellular and molecular studies in the pathogenic fungi Paracoccidioides brasiliensis: Dimorphism and its regulation by steroid hormones
• Epidemiology profile of dermatophytosis in Braga
• Elucidation of the mechanisms of action of non-conventional antifungal agents
• Exploitation of yeast as a model to study mitochondrial diseases and neurodegenerative disorder Batten disease
• Apoptotic pathway(s) in Saccharomyces cerevisiae: proteomic profile and metacaspase-interactive molecules
• Identification of pathogenic fungi secreted compounds
• Biology of infection in mycobacteriosis of difficult treatment- Buruli Ulcer
• Understanding BCG infection/vaccination; role of IFN-gamma and IL-17
• Role of anti-inflammatory cytokines in allograft rejection
• Expression and activation of murine Toll-like receptors in B lymphocytes
• Development of drug delivery systems for the treatment of mycobaceriosis
B – Neurosciences
• Neuronal turnover regulation and its relevance for pathology
• From stress to cognition and pain: the role of corticosteroids and CRF
• Descending pain modulating networks
• Anatomical basis for the sensorymotor processing in the laryngeal mucosa
• Improving treatment of trigeminal neuralgia (TN) and epidemiology of TN in Portugal
• Studies on the role of transthyretin in energy metabolism
• Molecular basis of schizophrenia: the retinoid and thyroid hormone hypotheses
• Characterization of the iodine status in young women from Minho region and its relationship with the psychomotor development of the newborns
• Functional genomics of Machado-Joseph disease
• Rett Syndrome
• Functional characterization of the MECP2 3'UTR
C – Development and Neoplasia
• Analysis of myopithelial component role in breast cancer development
• Analysis of DNA repair gene polymorphisms in a group of breast cancer patients from Portuguese origin
• Study of lymphangiogenesis in vascular lesions and breast cancer
• Analysis of receptor tyrosine kinases and intracellular signaling pathway alterations in gliomas
• Role of COX-2 and TP in the antitumoral response to Capecitabine in Hand and Foot Syndrome animal model
• The molecular clock is operating during limb bud development
• Characterization of the molecular clock components by using the yeast Two-Hybrid technology
• Subtraction screening to identify medial presomitic mesoderm genes
• Molecular and temporal characterization of the rostral-most somites in early somitic stages of the chick embryo
• The role of ghrelin in normal and hypoplastic fetal lung
• Prognostic factors in experimental and human congenital diaphragmatic hernia (CDH)
• The role of inflammatory mediators in normal and hypoplastic lung
• Induction of fetal lung growth by overexpression of growth factors through viral gene transfer in CDH rat model
• In utero fate mapping of Aorta-Gonad-Mesonephros cells
• Myocardium hypertrophy and pregnancy
• Fetal heart development in congenital diaphragmatic hernia
• Ghrelin expression and function during fetal heart development
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