Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/13193
Título: | Synthesis of temperature-responsive Dextran-MA/PNIPAAm particles for controlled drug delivery using superhydrophobic surfaces |
Autor(es): | Lima, A. C. Wenlong Song Blanco-Fernandez, Barbara Alvarez-Lorenzo, Carmen Mano, J. F. |
Palavras-chave: | Biomimetics Delivery systems Dextran- methacrylate Encapsulation methods Inter-penetrated networks PNIPAAm Smart systems Superhydrophobic surfaces |
Data: | 5-Fev-2011 |
Editora: | Springer |
Revista: | Pharmaceutical Research |
Resumo(s): | Purpose: To implement a bioinspired methodology using superhydrophobic surfaces suitable for producing smart hydro- gel beads in which the bioactive substance is introduced in the particles during their formation. Methods: Several superhydrophobic surfaces, including polystyrene, aluminum and copper, were prepared. Polymeric solutions composed by photo-crosslinked dextran-methacrylated and thermal responsive poly(N-isopropylacrylamide) mixed with a protein (insulin or albumin) were dropped on the superhydrophobic surfaces, and the obtained millimetric spheres were hardened in a dry environment under UV light. Results: Spherical and non-sticky hydrogels particles were formed in few minutes on the superhydrophobic surfaces. The proteins included in the liquid formulation were homogeneously distributed in the particle network. The particles exhibited temperature-sensitive swelling, porosity and protein release rate, with the responsiveness tunable by the dextran-MA/PNIPAAm weight ratio.Conclusions: The proposed method permitted the preparation of smart hydrogel particles in one step with almost 100% encapsulation yield. The temperature-sensitive release profiles suggest that the obtained spherical-shaped biomaterials are suitable as protein carriers. These stimuli-responsive beads could have potential to be used in pharmaceutical or other biomedical applications, including tissue engineering and regenerative medicine. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/13193 |
DOI: | 10.1007/s11095-011-0380-2 |
ISSN: | 0724-8741 1573-904X |
Versão da editora: | http://www.springerlink.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Synthesis of Temperature-Responsive Dextran-MA-PNIPAAm.pdf | Documento principal | 803,35 kB | Adobe PDF | Ver/Abrir |