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https://hdl.handle.net/1822/13424| Título: | Supercritical antisolvent precipitation of PHBV microparticles |
| Autor(es): | Costa, M. S. Duarte, Ana Rita C. Cardoso, M. M. Duarte, Catarina M. M. |
| Palavras-chave: | Supercritical fluids Micronization SAS Natural polymers PHBV Drug delivery |
| Data: | 2007 |
| Editora: | Elsevier 1 |
| Revista: | International Journal of Pharmaceutics |
| Resumo(s): | The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SASexperiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 mwere obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a dichloromethane (DCM) solution. The best process conditions for this mixture were, according to our study, 40 ◦C, 100 bar, 1mLmin−1 liquid flow and 10 L min−1 carbon dioxide flow. Experiments with polymers containing different HV percentages were carried out. The powders obtained became more spherical as the HV content decreased. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/13424 |
| ISSN: | 0378-5173 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
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