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https://hdl.handle.net/1822/56850
Título: | Novel nano-engineering phytantriol-F127-based cubosomes for antibiotic delivery |
Autor(es): | Domingues, Joana Margarida Dias Pereira, Maria Olívia Sousa, Ana Margarida Silva, Bruno F. B. |
Data: | 2-Out-2018 |
Citação: | Domingues, Joana; Pereira, Maria Olívia; Sousa, Ana Margarida; Silva, B. F. B., Novel nano-engineering phytantriol-F127-based cubosomes for antibiotic delivery. CHEMPOR 2018 - 13th International Chemical and Biological Engineering Conference (Book of Extended Abstracts). No. O-BB14, Aveiro, Portugal, Oct 2-4, 52-53, 2018. |
Resumo(s): | Nanoparticles exhibited exceptional properties for drug delivery via different routes with excellent pharmacokinetics profiles using minimal dosages with almost no systemic side effects. The delivery of drug molecules for therapeutic applications usually faces problems of solubility and bioavailability that cubosomes can easily overcome. Cubosomes are cubic lipid-based nanoparticles with increased surface area, low viscosity and high heat stability. The preparation of cubosomes and drug encapsulation are still procedures requiring important improvements that have limit their use as drug delivery system. This work we developed a simple experimental procedure able to produce controlled-size cubosomes with different hydrodynamic size dependent of the phytantriol/ethanol (lipid/hydrotrope) ratio. Moreover, cubosomes were easily loaded with ciprofloxacin without structural changes. The results of this study will greatly impact on the applicability of cubosomes as drug delivery system. |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/56850 |
Versão da editora: | http://www.chempor2018.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_49095_1.pdf | 191,95 kB | Adobe PDF | Ver/Abrir |