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https://hdl.handle.net/1822/57951
Título: | Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study |
Autor(es): | Taipa, Ricardo Jorge Ferreira Ferreira, V. Brochado, P. Robinson, A Reis, I. Marques, Fernanda Mann, D. M. Melo-Pires, M. Sousa, Nuno |
Palavras-chave: | Ageing Alzheimer´s disease Astrocytes Microglia Pathology |
Data: | 2018 |
Editora: | Wiley |
Revista: | Neuropathology and Applied Neurobiology |
Citação: | Taipa, R., Ferreira, V., Brochado, P., Robinson, A., Reis, I., Marques, F., ... & Sousa, N. (2018). Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study. Neuropathology and applied neurobiology, 44(3), 298-313 |
Resumo(s): | The association between the pathological features of AD and dementia is stronger in younger old persons than in older old persons suggesting that additional factors are involved in the clinical expression of dementia in the oldest old. Cumulative data suggests that neuroinflammation plays a prominent role in Alzheimer's disease (AD) and different studies reported an age-associated dysregulation of the neuroimmune system. Consequently, we sought to characterize the pattern of microglial cell activation and astrogliosis in brain post mortem tissue of pathologically confirmed cases of early and late onset AD (EOAD and LOAD) and determine their relation to age. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/57951 |
DOI: | 10.1111/nan.12445 |
ISSN: | 0305-1846 |
e-ISSN: | 1365-2990 |
Versão da editora: | https://onlinelibrary.wiley.com/doi/full/10.1111/nan.12445 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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TAIPAR~1.PDF | 1,43 MB | Adobe PDF | Ver/Abrir |