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https://hdl.handle.net/1822/58734
Título: | Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells |
Autor(es): | Oliveira, Catarina Neves, N. M. Reis, R. L. Martins, A. Silva, T. H. |
Palavras-chave: | breast cancer cells Chitosan Drug Delivery System endothelial cells Fucoidan gemcitabine Nanoparticles Polyelectrolyte complexation |
Data: | Set-2018 |
Editora: | Future Medicine Ltd |
Revista: | Nanomedicine |
Citação: | Oliveira C., Neves N. M., Reis R. L., Silva T. H., Martins A. Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells, Nanomedicine, doi:10.2217/nnm-2018-0004, 2018 |
Resumo(s): | Aim: To produce marine-origin nanoparticles (NPs) aiming to develop more effective and tolerated therapies for breast cancer. Materials & methods: NPs based in two marine-origin polymers (fucoidan and chitosan) were prepared by polyelectrolyte complexation, for the delivery of an antitumor drug model (gemcitabine [Gem]). Results: Final formulation resulted in stable NPs around 115â 140 nm in size and with a polydispersity index less than 0.2. Gem was encapsulated at a maximum entrapment efficiency of 35â 42%. Drug-release studies demonstrated that around 84% of Gem is released within 4 h. Cytotoxicity results of Gem-loaded NPs showed increased toxicity (around 25%) when compared with free Gem. Conclusion: The drug-loaded NPs present increased toxicity over human breast cancer cells without increasing toxic effects over endothelial cells. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58734 |
DOI: | 10.2217/nnm-2018-0004 |
ISSN: | 1743-5889 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19674-nnm-2018-0004.pdf | 2,87 MB | Adobe PDF | Ver/Abrir |