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https://hdl.handle.net/1822/61454
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Campo DC | Valor | Idioma |
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dc.contributor.author | Baptista, Maria João Ribeiro Leite | por |
dc.contributor.author | Rocha, Gustavo | por |
dc.contributor.author | Clemente, Fátima | por |
dc.contributor.author | Azevedo, Luís F. | por |
dc.contributor.author | Tibboel, Dick | por |
dc.contributor.author | Leite-Moreira, Adelino F. | por |
dc.contributor.author | Guimarães, Hercília | por |
dc.contributor.author | Areias, José C. | por |
dc.contributor.author | Correia-Pinto, Jorge | por |
dc.date.accessioned | 2019-09-23T11:13:29Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1661-7800 | - |
dc.identifier.uri | https://hdl.handle.net/1822/61454 | - |
dc.description.abstract | Objective: In congenital diaphragmatic hernia (CDH) the severity of pulmonary hypertension (PH) is considered, by several authors, determinant of clinical outcome. Plasmatic N-terminal-pro-B type natriuretic peptide (NT-proBNP) might be useful in diagnosis and management of PH in newborns, although its interest in CDH infants remains to be defined. Early NT-proBNP levels were assessed in CDH infants and correlated with cardiovascular echocardiographic parameters. Patients and Methods: 28 newborns, CDH and age-matched controls were enrolled in a prospective study. Clinical condition, NT-proBNP plasmatic levels, echo parameters of PH and biventricular function were assessed at 24 h after delivery as well as survival outcome. Results: Estimated mean pulmonary pressure and NT-proBNP were significantly higher in CDH than control infants. NT-proBNP significantly correlated with estimated pulmonary artery pressure, right ventricular Tei index, and tricuspid E/A ratio. Additionally, we found that CDH infants with NT-proBNP >11,500 pg/ml experienced a worse prognosis. Conclusions: We demonstrated that PH is associated with NT-proBNP elevation and diastolic impairment in CDH infants. Early elevations in NT-proBNP levels seem to alert for a subset of CDH infants with worse prognosis. | por |
dc.description.sponsorship | This study was funded by Fundação para a Ciência e Tecnologia (FCT) through the research project SAU-OBS/56428/2004 | por |
dc.language.iso | eng | por |
dc.publisher | Karger Publishers | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POCI/56428/PT | por |
dc.rights | closedAccess | por |
dc.subject | Blood Pressure | por |
dc.subject | Case-Control Studies | por |
dc.subject | Echocardiography | por |
dc.subject | Female | por |
dc.subject | Heart | por |
dc.subject | Hernia, Diaphragmatic | por |
dc.subject | Humans | por |
dc.subject | Hypertension, Pulmonary | por |
dc.subject | Infant, Newborn | por |
dc.subject | Male | por |
dc.subject | Natriuretic Peptide, Brain | por |
dc.subject | Peptide Fragments | por |
dc.subject | Prognosis | por |
dc.subject | Prospective Studies | por |
dc.subject | Severity of Illness Index | por |
dc.subject | Hernias, Diaphragmatic, Congenital | por |
dc.subject | N-terminal-pro-B type natriuretic peptide | por |
dc.subject | Cardiac function | por |
dc.subject | Diastole | por |
dc.subject | congenital diaphragmatic hernia | por |
dc.subject | pulmonary hypertension | por |
dc.title | N-terminal-pro-B type natriuretic peptide as a useful tool to evaluate pulmonary hypertension and cardiac function in CDH infants | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 22 | por |
oaire.citationEndPage | 30 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 94 | por |
dc.identifier.eissn | 1661-7819 | - |
dc.identifier.doi | 10.1159/000112641 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 18160811 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Neonatology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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baptista2007.pdf Acesso restrito! | 199,9 kB | Adobe PDF | Ver/Abrir |