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https://hdl.handle.net/1822/61457
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Carvalho, Agostinho | por |
dc.contributor.author | Santos, M. | por |
dc.contributor.author | Maciel, P. | por |
dc.contributor.author | Rodrigues, Fernando José dos Santos | por |
dc.date.accessioned | 2019-09-23T12:40:19Z | - |
dc.date.issued | 2008-05 | - |
dc.identifier.issn | 1352-4585 | - |
dc.identifier.uri | https://hdl.handle.net/1822/61457 | - |
dc.description.abstract | Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, with disturbances of the immunological balance. As TLR9-null mice showed increased resistance to experimental autoimmune encephalomyelitis and recent genetic investigations showed that T-1237C promoter polymorphism of TLR9, commonly implicated in autoimmune diseases, induces a deregulation of its expression, we performed an association study in a Portuguese population of 165 MS patients and unrelated healthy controls. Our results show no significant association with MS and no protective effect of T-1237C concerning age of onset, disease severity or disease subtype in MS patients. | por |
dc.description.sponsorship | Carvalho A (grant SFRH/BD/11837/2003) and Santos M (grant SFRH/BD/9111/2002) were financially supported by Fundação para a Ciência e Tecnologia, Portugal. This study was supported by Fundação para a Ciência e Tecnologia, Portugal (POCI/SAU-ESP/61080/2004). | por |
dc.language.iso | eng | por |
dc.publisher | SAGE Publications | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F11837%2F2003/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F9111%2F2002/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POCI/61080/PT | por |
dc.rights | closedAccess | por |
dc.subject | Adult | por |
dc.subject | Age of Onset | por |
dc.subject | Female | por |
dc.subject | Genetic Predisposition to Disease | por |
dc.subject | Genotype | por |
dc.subject | Humans | por |
dc.subject | Male | por |
dc.subject | Middle Aged | por |
dc.subject | Multiple Sclerosis | por |
dc.subject | Portugal | por |
dc.subject | Promoter Regions, Genetic | por |
dc.subject | Severity of Illness Index | por |
dc.subject | Toll-Like Receptor 9 | por |
dc.subject | Polymorphism, Genetic | por |
dc.subject | Disease | por |
dc.subject | Inflammation | por |
dc.subject | Innate immunity | por |
dc.subject | Susceptibility | por |
dc.subject | toll-like receptor | por |
dc.title | T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 550 | por |
oaire.citationEndPage | 552 | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 14 | por |
dc.identifier.eissn | 1477-0970 | - |
dc.identifier.doi | 10.1177/1352458507084594 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 18208876 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Multiple Sclerosis | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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carvalho2008 (1).pdf Acesso restrito! | 138,77 kB | Adobe PDF | Ver/Abrir |