Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62307
Título: | Antibacterial free-standing polysaccharide composite films inspired by the sea |
Autor(es): | Vale, A. Catarina Pereira, Paulo R. Barbosa, Ana Margarida Martins Torrado, Egídio Mano, J. F. Alves, N. M. |
Palavras-chave: | Animals Anti-Bacterial Agents Biomimetic Materials Ceramics Nanoparticles Polysaccharides Silver Tensile Strength Wettability Bivalvia Natural-derived polysaccharides Free-standings film Silver containing bioglass nanoparticles Free-standings films |
Data: | 15-Jul-2019 |
Editora: | Elsevier 1 |
Revista: | International Journal of Biological Macromolecules |
Resumo(s): | The adhesive capabilities of marine mussel proteins are well-known, exhibiting the ability to stick to different underwater substrates, either inorganic or organic. These unique adhesive properties are due to the high levels of amino acid, 3,4-dihydroxyphenyl-l-alanine (DOPA), which presents the reactive catechol group. Herein, novel antibacterial free-standing (FS) films were developed with natural polymers, namely chitosan (CHT) and hyaluronic acid (HA), being the catechol-functionalized hyaluronic acid (HA-DN) also included to provide wet adhesive properties. In order to obtain composite films, silver doped bioglass nanoparticles (Ag-BGs) were incorporated to promote bactericidal and bioactive properties, being tested four distinct formulations of FS films. Their surface morphology and topography, wettability, weight loss, swelling, mechanical, adhesion and bioactivity was analyzed. In particular, bioactivity tests revealed that upon immersion in simulated body fluid, there was the formation of a bone-like apatite layer. Moreover, upon 16 h in direct contact with Staphylococcus aureus and Escherichia coli cultures, these FS films exhibited a clear antibacterial effect. Therefore, such bioactive, antibacterial and adhesive free-standing films could potentially be used as temporary guided bone regeneration films, in particular to regenerate small bone defects and also periodontal tissues. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62307 |
DOI: | 10.1016/j.ijbiomac.2019.04.102 |
ISSN: | 0141-8130 |
e-ISSN: | 1879-0003 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Vale AC et al. Int J Biol Macromol.pdf | 2,17 MB | Adobe PDF | Ver/Abrir |