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https://hdl.handle.net/1822/74857
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Campo DC | Valor | Idioma |
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dc.contributor.author | Lemos, Rafael | por |
dc.contributor.author | Maia, F. Raquel | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Oliveira, J. M. | por |
dc.date.accessioned | 2021-12-03T16:36:03Z | - |
dc.date.available | 2021-12-03T16:36:03Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2021-12 | - |
dc.identifier.citation | Lemos R., Maia F. R., Reis R. L., Oliveira J. M. Engineering of Extracellular Matrix-Like Biomaterials at Nano- and Macroscale toward Fabrication of Hierarchical Scaffolds for Bone Tissue Engineering, Advanced NanoBiomed Research, doi:10.1002/anbr.202100116, 2021 | por |
dc.identifier.issn | 2699-9307 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74857 | - |
dc.description.abstract | The increasing rate of musculoskeletal pathologies has compelled the development of improved and novel treatment strategies in order to address unmet clinical needs. Tissue engineering approaches comprising the use of scaffolds for bone regeneration have been showing to be a promising alternative to conventional bone repair/substitution approaches. In particular, hierarchical scaffolds as methods of structural support and osteogenic differentiation promoters are among the most used tools in bone tissue engineering (BTE). In this reasoning, hierarchical scaffolds have sparked the field, striving toward mimicking the natural bone tissue in both, its complex 3D structure and composition. A recent and promising trend has been the merging of nanotechnology and tissue engineering concepts. As such the incorporation of nanoparticles and nanocomposites into micro- or macroscaffold systems can result in an improvement of scaffoldsâ biofunctionality at different levels. These tools are versatile in nature and can be used for multiple purposes such as drug delivery, thermal conductors, and mechanical reinforcement. Taking into consideration multidisciplinary approaches, several strategies have been pursued. The recent reports dealing with the approaches pursued in the hierarchical scaffolds production and enhancement, ranging from the nanoscale to the macroscale, are overviewed herein. | por |
dc.description.sponsorship | The authors thank the funds provided by the project FROnTHERA (NORTE-01-0145-FEDER-000023), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), the project 3BioMeD (FCT/4773/ 4/5/2017/S) supported by Fundação para a Ciência e a Tecnologia (FCT) and the R&D Project KOAT PTDC/BTMMAT/29760/2017 (POCI 01-0145-FEDER-029760) financed by FCT and cofinanced by FEDER and POCI. F.R.M. acknowledges FCT for her contract under the Transitional Rule DL 57/2016 (CTTI-57/18-I3BS (5)). | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-MAT%2F29760%2F2017/PT | por |
dc.rights | openAccess | por |
dc.subject | Biomaterials | por |
dc.subject | Bone | por |
dc.subject | Microparticles | por |
dc.subject | Nanocomposites | por |
dc.subject | Nanoparticles | por |
dc.title | Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineering | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/anbr.202100116 | por |
dc.comments | http://3bs.uminho.pt/node/20633 | por |
oaire.citationIssue | 2 | por |
oaire.citationVolume | 2 | por |
dc.date.updated | 2021-12-03T15:36:54Z | - |
dc.identifier.doi | 10.1002/anbr.202100116 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Advanced NanoBiomed Research | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20633-engineering-extracellular-matrix-biomaterials-nano-and-macroscale-toward-fabrication-hierarchical-sc.pdf | 4,14 MB | Adobe PDF | Ver/Abrir |