Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/78773
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Loureiro, Daniela R. P. | por |
dc.contributor.author | Magalhães, Álvaro F. | por |
dc.contributor.author | Soares, José X. | por |
dc.contributor.author | Pinto, Joana | por |
dc.contributor.author | Azevedo, Carlos M. G. | por |
dc.contributor.author | Vieira, Sara | por |
dc.contributor.author | Henriques, Ana | por |
dc.contributor.author | Ferreira, Helena Susana Costa Machado | por |
dc.contributor.author | Neves, N. M. | por |
dc.contributor.author | Bousbaa, Hassan | por |
dc.contributor.author | Reis, Salette | por |
dc.contributor.author | Afonso, Carlos M. M. | - |
dc.contributor.author | Pinto, Madalena M. M. | - |
dc.date.accessioned | 2022-07-13T14:40:07Z | - |
dc.date.available | 2022-07-14T06:00:21Z | - |
dc.date.issued | 2020-03 | - |
dc.date.submitted | 2020-03 | - |
dc.identifier.citation | Loureiro D. R. P., Magalhães A. F., Soares J. X., Pinto J., Azevedo C. M. G., Vieira S. F., Henriques A., Ferreira H., Neves N. M., Bousbaa H., Reis S., Afonso C. M. M., Pinto M. M. M. Yicathins B and C and analogues: total synthesis, lipophilicity and biological activities, ChemMedChem, doi:10.1002/cmdc.201900735, 2020 | por |
dc.identifier.issn | 1860-7187 | por |
dc.identifier.uri | https://hdl.handle.net/1822/78773 | - |
dc.description.abstract | Natural products had always be an important source of new hits and leads in drug discovery. The marine environment has been regarded as a significant souce of novel and exquisite bioactive compounds. Yicathins B and C are two marine derived xanthones that have shown antibacterial and antifungal activities. Herein, the total synthesis of these yicathins is reported for the first time as well as six novel analogues. As marine natural products tend to bear very lipophilic scaffolds, the lipophilicity of yicathins and its analogues was evaluated using the classical octanol:water system and a biomimetic model based system. As the xanthonic nucleus is a â privileged structureâ , other biological activities were evaluated, namely antitumor and anti-inflammatory activities. An interesting anti-inflammatory activity was identified for yicathins analogues that paves the way for the design of dual activity (anti-infective and anti-inflammatory) marine inspired xanthones derivatives. | por |
dc.description.sponsorship | This work was supported through national funds provided by FCT/MCTES - Foundation for Science and Technology from the Minister of Science, Technology and Higher Education (PIDDAC) and European Regional Development Fund (ERDF) through the COMPETE - Programa Operacional Factores de Competitividade (POFC) programme, under the projects PTDC/MAR-BIO/4694/2014 (reference POCI-01-0145-FEDER-016790; Project 3599 - Promover a ProducAo Cientifica e Desenvolvimento Tecnologico e a ConstituicAo de Redes Tematicas (3599-PPCDT)) and PTDC/SAU-PUB/28736/2017 (reference POCI-01-0145-FEDER- 028736) in the framework of the programme PT2020. D. R. P. L. is grateful for research grant PTDC/MAR-BIO/4694/2014-BI-2017-003. J. X. S. thanks the FCT PhD Programmes and Programa Operacional Capital Humano (POCH), specifically the BiotechHealth Programme (Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences), reference PD/00016/2012; through the FCT and POCH for PhD grants (SFRH/BD/98105/2013 and SFRH/BD/116167/2016). The authors would like to thank Sara Cravo and Gisela Adriano for the technical support, the Centro de Apoio Cientifico e Tecnoloxico a Investigation (C.A.C.T.I., University of Vigo, Pontevedra, Spain) for HRMS analysis, the Centro de Materiais da Universidade do Porto (CEMUP, Porto, Portugal) for HRMS, and the Departamento de Quimica da Universidade de Aveiro (Portuguese NMR network) for the NMR analysis. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley-VCH Verlag | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMAR-BIO%2F4694%2F2014/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FSAU-PUB%2F28736%2F2017/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMAR-BIO%2F4694%2F2014/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F98105%2F2013/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F116167%2F2016/PT | - |
dc.rights | openAccess | por |
dc.subject | Anti-inflammatory | por |
dc.subject | Lipophilicity | por |
dc.subject | Marine | por |
dc.subject | Total synthesis | por |
dc.subject | Xanthone | por |
dc.title | Yicathins B and C and analogues: total synthesis, lipophilicity and biological activities | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/cmdc.201900735 | por |
dc.comments | http://3bs.uminho.pt/node/20270 | por |
oaire.citationStartPage | 749 | por |
oaire.citationEndPage | 755 | por |
oaire.citationIssue | 9 | por |
oaire.citationVolume | 15 | por |
dc.date.updated | 2022-07-07T08:29:25Z | - |
dc.identifier.doi | 10.1002/cmdc.201900735 | por |
dc.identifier.pmid | 32162478 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | ChemMedChem | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20270-Yicathins B and C and analogues- total synthesis, lipophilicity and biological activities.pdf | 2,11 MB | Adobe PDF | Ver/Abrir |