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https://hdl.handle.net/1822/12848
Título: | Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology |
Autor(es): | Silva, Simone Santos Mano, J. F. Reis, R. L. Carvalho, Ana Paula Duarte, Ana Rita C. |
Palavras-chave: | Chitin Ionic liquids Supercritical fluid technology Green chemistry Biomedical applications Biomaterials Supercritical drying |
Data: | 2011 |
Editora: | Elsevier 1 |
Revista: | Acta Biomaterialia |
Citação: | Silva S. S., Duarte A. R. C., Carvalho A. P. B., Mano J. F., Reis R. L. Green processing of chitin porous structures for biomedical aapplications combining ionic liquids and supercritical fluid technology, Acta Biomaterialia, Vol. 7, pp. 1166-1172, doi:10.1016/j.actbio.2010.09.041, 2011 |
Resumo(s): | The application of green chemistry principles in the processing of materials for advanced technologies is a steadily increasing field of research. In this work porous chitin-based materials were developed by combining the processing of chitin using ionic liquids (ILs)as a green solvent together with the use of super- critical fluid technology(SCF) as clean technology.Chitin was dissolved in 1-butyl-3-imidazolium acetate,followed by regeneration of the polymer in ethanol in specific moulds.The IL was removed using Soxhlet extraction and successive steps of extraction with SCF using carbon dioxide/ethanol ratios of 50/ 50 and70/30.The developed porous chitin-based structures (ChIL)can be classified as mesoporous materials,with very low density and high porosity.The cytotoxicity of ChIL extracts was investigated using L929 fibroblast like cells,and the results demonstrated that the produced materials have extremely lowcytotoxicityl evels.Therefore,the findings suggest that the porous chitin structures may be potential candidates for a number of biomedical applications,including tissue engineering. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/12848 |
DOI: | 10.1016/j.actbio.2010.09.041 |
ISSN: | 1742-7061 |
e-ISSN: | 1878-7568 |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S1742706110004514 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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acta biomaterialia paper.pdf | Documento principal | 928,62 kB | Adobe PDF | Ver/Abrir |