Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/14070
Título: | Preparation of ethylcellulose/methylcellulose blends by supercritical antisolvent precipitation |
Autor(es): | Duarte, Ana Rita C. Gordillo, M. D. Cardoso, M. Margarida Simplicio, A. L. Duarte, Catarina M. M. |
Palavras-chave: | Biocompatible polymers Micronization Supercritical fluid antisolvent (SAS) Release systems |
Data: | 2006 |
Editora: | Elsevier 1 |
Revista: | International Journal of Pharmaceutics |
Resumo(s): | The supercritical antisolvent (SAS) techniquewas used to prepare ethyl cellulose/methyl cellulose blends, two biocompatible polymers commonly used as drug carriers in controlled delivery systems. Ethyl cellulose is widely used as a drug carrier. The drug release of the delivery devices can be controlled to some extent by addition of a water-soluble or water swellable polymer, such as methyl cellulose. This leads to the solubility enhancement of poorly water-soluble molecules. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 5 to 30 m were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a mixture of dichloromethane (DCM) and dimethylsulfoxide (DMSO) (4:1 ratio). The best process conditions for this mixture were according to our study 40 ◦C and 80 bar. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/14070 |
ISSN: | 0378-5173 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |