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https://hdl.handle.net/1822/14267| Título: | Ga(III) chelates of amphiphilic DOTA-based ligands : synthetic route and in vitro and in vivo studies |
| Autor(es): | Fontes, André Filipe Gomes Soares Prata, M. Isabel M. Geraldes, Carlos F. G. C. André, João P. |
| Palavras-chave: | DOTA Gallium Amphiphilic Micelles Radiopharmacy PET |
| Data: | 2011 |
| Editora: | Elsevier 1 |
| Revista: | Nuclear Medicine and Biology |
| Resumo(s): | In this work we report a synthetic strategy of amphiphilic DOTA-based chelators bearing a variable size α-alkyl chain at one of the pendant acetate arms (from six to fourteen carbon atoms), compatible with their covalent coupling to amine-bearing biomolecules. The amphiphilic behavior of the micelles-forming Ga(III) chelates (critical micelle concentration), their stability in blood serum and their lipophilicity (logP) were investigated. Biodistribution studies with the 67Ga-labeled chelates were performed in Wistar rats showing a predominant liver uptake with almost no traces of the radiochelates in the body after 24 hours. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/14267 |
| DOI: | 10.1016/j.nucmedbio.2010.10.003 |
| ISSN: | 0969-8051 |
| Versão da editora: | http://www.elsevier.com/wps/find/journaldescription.cws_home/525482/description |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: | CDQuim - Artigos (Papers) |
