Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/20451
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Bessa, Paulo C. | - |
dc.contributor.author | Balmayor, Elizabeth Rosado | - |
dc.contributor.author | Azevedo, Helena S. | - |
dc.contributor.author | Nürnberger, Sylvia | - |
dc.contributor.author | Casal, Margarida | - |
dc.contributor.author | van Griensven, M. | - |
dc.contributor.author | Reis, R. L. | - |
dc.contributor.author | Redl, Heinz | - |
dc.date.accessioned | 2012-10-18T10:20:58Z | - |
dc.date.available | 2012-10-18T10:20:58Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1932-7005 | por |
dc.identifier.uri | https://hdl.handle.net/1822/20451 | - |
dc.description.abstract | Bone morphogenetic proteins (BMPs) are cytokines with strong ability to promote new bone formation. Herein, we report the use of silk fibroin microparticles as carriers for the delivery of BMP-2, BMP-9 or BMP-14. BMP-containing fibroin microparticles were prepared by a mild methodology using dropwise addition of ethanol, exhibiting mean diameters of 2.7 ± 0.3 μm. Encapsulation efficiencies varied between 67.9 ± 6.1 % and 97.7 ± 2.0 % depending on the type and the amount of BMP loaded. Release kinetics showed that BMP-2, BMP-9 and BMP-14 were released in two phases profile, with a burst release in the first two days followed by a slower release, for a period of 14 days. The release data were best explained by Korsmeyer’s model and the Fickian model of drug diffusion. Silk fibroin microparticles can offer a promising approach for the sustained delivery of different BMPs in tissue engineering applications. | por |
dc.description.sponsorship | The authors wish to acknowledge. Susana Moreira, Elsa Ribeiro and Katharina Schobitz for critical input. This work was supported by Fundacao para a Ciencia e Tecnologia (PhD grant SFRH/BD/17049/2004), project ElastM POCI/CTM/57177/2004 funded by FEDER and the Fundacao para a Ciencia e Tecnologia; Marie Curie Alea Jacta EST short-term grant (MEST-CT-2004-8104) and European STREP Project HIPPOCRATES (NMP3-CT-2003-505758). This work was carried out under the scope of the European NoE EXPERTISSUES (NMP3-CT-2004-500283). | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F17049%2F2004/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/POCI/57177/PT | - |
dc.relation | NMP3-CT-2003-505758 | - |
dc.relation | NMP3-CT-2004-500283 | - |
dc.rights | openAccess | por |
dc.subject | Bone morphogenetic protein | por |
dc.subject | Silk fibroin | por |
dc.subject | Microparticles | por |
dc.subject | Drug delivery | por |
dc.subject | MP-2 | por |
dc.subject | BMP-9 | por |
dc.subject | BMP-14 | por |
dc.subject | BMP-2 | por |
dc.title | Silk fibroin microparticles as carriers for delivery of human recombinant BMPs: physical characterization and drug release | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 349 | por |
oaire.citationEndPage | 355 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 4 | por |
dc.identifier.doi | 10.1002/term.245 | por |
dc.identifier.pmid | 20058243 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Tissue Engineering and Regenerative Medicine | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |