Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/20719
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Campo DC | Valor | Idioma |
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dc.contributor.author | González-Pérez, Javier | - |
dc.contributor.author | Villa-Collar, César | - |
dc.contributor.author | González-Méijome, José Manuel | - |
dc.contributor.author | Garcia-Porta, Nery | - |
dc.contributor.author | Parafita, Manuel A. | - |
dc.date.accessioned | 2012-11-07T14:37:38Z | - |
dc.date.available | 2012-11-07T14:37:38Z | - |
dc.date.issued | 2012 | - |
dc.date.submitted | 2012-07-02 | - |
dc.identifier.citation | González-Pérez J, Villa-Collar C, González-Méijome JM, Porta NG, Parafita MÁ. Long-term changes in corneal structure and tear inflammatory mediators after orthokeratology and LASIK. Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5301-11. doi: 10.1167/iovs.11-9155. | por |
dc.identifier.issn | 0146-0404 | por |
dc.identifier.uri | https://hdl.handle.net/1822/20719 | - |
dc.description.abstract | PURPOSE: To monitor changes in corneal structure and level of inflammatory mediators in tears of myopic patients following orthokeratology (OK) and laser in situ keratomileusis (LASIK). METHODS: Sixty-two myopic subjects were analyzed in this prospective study. Thirty-two had worn Paragon CRT contact lenses and 30 underwent standard LASIK. Thirty-two control subjects were also recruited. Pachometry and corneal topography were performed 12 months after both interventions. Tears were collected and assayed using ELISA for IL-6, IL-8, matrix metalloproteinase-9 (MMP-9), and epidermal growth factor (EGF). RESULTS: Corneal power decreased in the central area and increased in the paracentral area. Simultaneously, there was a central corneal thinning with mid-peripheral thickening for OK. No changes were observed for LASIK. In comparison with controls, IL-6, IL-8, MMP-9, and EGF levels were increased significantly for OK (P < 0.01). Only MMP-9 (P < 0.01) and EGF (P < 0.01) were increased for LASIK. Pro-inflammatory response was found to be associated with the degree of myopia in the OK group. The MMP-9 and EGF upregulation was linked to the presence of iron deposition in both groups, whereas increased levels of EGF were connected with the presence of myopic regression after LASIK. CONCLUSIONS: Both interventions involved important tissue reshaping. The physical presence of a reverse geometry contact lens caused certain markers to change significantly in comparison with no lens wear or LASIK in the long-term response. MMP-9 was significantly higher in tears of subjects presenting iron deposition after OK or LASIK, and EGF levels seemed to play an important role in postoperative refractive outcomes after LASIK. | por |
dc.description.sponsorship | Supported by National Grant PI081380 from Instituto de Salud Carlos III, Spain, awarded to the Ocular Surface and Contact Lens Research Group GI-1750. | por |
dc.language.iso | eng | por |
dc.publisher | Association for Research in Vision and Ophthalmology (ARVO) | por |
dc.rights | openAccess | por |
dc.subject | Inflammatory mediators | por |
dc.subject | Orthokeratology | por |
dc.title | Long-term changes in corneal structure and tear inflammatory mediators after orthokeratology and LASIK | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.iovs.org/cgi/pmidlookup?view=long&pmid=22789928 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 5301 | por |
oaire.citationEndPage | 5311 | por |
oaire.citationIssue | 9 | por |
oaire.citationTitle | Investigative Ophthalmology & Visual Science | por |
oaire.citationVolume | 53 | por |
dc.identifier.doi | 10.1167/iovs.11-9155 | por |
dc.identifier.pmid | 22789928 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Investigative Ophthalmology & Visual Science | por |
Aparece nas coleções: | CDF - OCV - Artigos/Papers (with refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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5.5.75. GONZALEZ-PEREZ_12_IOVS (Inflammatory Mediators OrtoK and LASIK).pdf | PDF version | 874,79 kB | Adobe PDF | Ver/Abrir |