Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22511
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Costa, Marta Sílvia Freitas da | - |
dc.contributor.author | Areias, F. | - |
dc.contributor.author | Abrunhosa, Luís | - |
dc.contributor.author | Venâncio, Armando | - |
dc.contributor.author | Proença, M. Fernanda R. P. | - |
dc.date.accessioned | 2013-01-10T16:52:35Z | - |
dc.date.available | 2013-01-10T16:52:35Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0022-3263 | por |
dc.identifier.issn | 1520-6904 | - |
dc.identifier.uri | https://hdl.handle.net/1822/22511 | - |
dc.description.abstract | The reaction of salicylic aldehydes with malononitrile was reinvestigated, and the reaction pathway was followed by 1H NMR spectroscopy. A delicate control of the experimental conditions allowed the synthesis of 2-imino-2H-chromene-3-carbonitriles 1, (2-amino-3-cyano-4H-chromen-4-yl)malononitriles 2, 4-amino-5-imino-2,7-dimethoxy-5H-chromeno[3,4-c]pyridine-1-carbonitrile 12, and (4,5-diamino-1-cyano-1,10b-dihydro-2H-chromeno[3,4-c]pyridin-2-ylidene)malononitrile 13. Two novel 2-iminochromene dimers, with structures 8 and 9, were isolated and fully characterized. The activity of compound 8a on Aspergillus spp. growth and on ochratoxin A production was evaluated. The results of the bioassays indicate that compound 8a, applied at concentrations of 2 mM, totally inhibited the growth of the fungi tested. Ochratoxin A production by Aspergillus alliaceus was reduced by about 93% with a 200 μM solution of this compound. A moderate inhibitory effect was observed for the analogous structure 8b, and no inhibition was registered for compounds 2 and 1, used as synthetic precursors of the dimeric species 8. | por |
dc.language.iso | eng | por |
dc.publisher | American Chemical Society (ACS) | por |
dc.rights | openAccess | por |
dc.title | The condensation of salicylaldehydes and malononitrile revisited : synthesis of new dimeric chromene derivatives | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://pubs.acs.org/ | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1954 | por |
oaire.citationEndPage | 1962 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 73 | por |
dc.identifier.doi | 10.1021/jo702552f | por |
dc.identifier.pmid | 18271600 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Organic Chemistry | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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jo702552f.pdf | 216,32 kB | Adobe PDF | Ver/Abrir |