Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/25632
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Longatto Filho, Adhemar | - |
dc.contributor.author | Hammes, L. Serpa | - |
dc.contributor.author | Sarian, L. | - |
dc.contributor.author | Roteli-Martins, C. | - |
dc.contributor.author | Derchain, S. | - |
dc.contributor.author | Eržen, M. | - |
dc.contributor.author | Branca, M. | - |
dc.contributor.author | Tatti, S. | - |
dc.contributor.author | Naud, P. | - |
dc.contributor.author | Matos, J. C. | - |
dc.contributor.author | Gontijo, R. | - |
dc.contributor.author | Maeda, Marina Yoshiê Sakamoto | - |
dc.contributor.author | Lima, Temístocles | - |
dc.contributor.author | Costa, S. | - |
dc.contributor.author | Syrjänen, S. | - |
dc.contributor.author | Syrjänen, K. | - |
dc.date.accessioned | 2013-10-09T14:20:28Z | - |
dc.date.available | 2013-10-09T14:20:28Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0378-7346 | por |
dc.identifier.uri | https://hdl.handle.net/1822/25632 | - |
dc.description.abstract | AIMS: To evaluate the role of hormonal contraceptives as a risk factor of high-risk human papillomavirus (HR-HPV), cervical intraepithelial lesions (CIN) and cervical cancer in our multi-center population-based LAMS (Latin American Screening) study. METHODS: A cohort study with >12,000 women from Brazil and Argentina using logistic regression to analyze the covariates of hormonal contraception (HOC - oral, injections, patches, implants, vaginal ring and progesterone intrauterine system) use followed by multivariate modeling for predictors of HR-HPV and CIN2+. RESULTS: HR-HPV infection was a consistent risk factor of high-grade CIN in all three groups of women. The length of HOC use was not significantly related to high-grade squamous intraepithelial lesions (HSIL)+ Pap (p = 0.069), LSIL+ Pap (p = 0.781) or ASCUS+ (p = 0.231). The same was true with the length of HOC use and histology CIN3+ (p = 0.115) and CIN2+ (p = 0.515). Frequently, HOC users have previously shown more HPV-related lesions, as well as lower HPV prevalence if they were current smokers. But HOC use and time of usage were not independent risk factors of either HR-HPV infection or high-grade CIN using multiple logistic regressions. CONCLUSIONS: No evidence was found for an association between the use of HOC with an increased risk for HR-HPV infection or high-grade CIN in this cohort. | por |
dc.description.sponsorship | This study is a part of the ongoing LAMS (Latin American Screening) study, entitled: Improving Health Systems Towards Equality-Based Control of Cervical Cancer in Latin America, and is supported by the INCO-DEV Program of the European Commission (Project No. ICA4-CT-2001-10013). The generous contribution of Digene Corporation (USA) who donated the HCII tests at our disposal is gratefully acknowledged. | por |
dc.language.iso | eng | por |
dc.publisher | Karger AG | por |
dc.rights | openAccess | por |
dc.subject | Hormonal contraceptives | por |
dc.subject | Cervical intraepithelial lesions | por |
dc.subject | High-risk human papillomavirus | por |
dc.subject | Cohort study | por |
dc.title | Hormonal contraceptives and the length of their use are not independent risk factors for high-risk HPV infections or high-grade CIN | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.karger.com/Article/FullText/320742 | por |
oaire.citationStartPage | 93 | por |
oaire.citationEndPage | 103 | por |
oaire.citationIssue | 2 | por |
oaire.citationTitle | Gynecologic and Obstetric Investigation | por |
oaire.citationVolume | 71 | por |
dc.date.updated | 2013-09-30T13:11:58Z | - |
dc.identifier.doi | 10.1159/000320742 | por |
dc.identifier.pmid | 21150159 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Gynecologic and Obstetric Investigation | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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longatto-filho a_gynec obst inv 2011 posp.pdf | 172,28 kB | Adobe PDF | Ver/Abrir |