Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/27317
Título: | Studies on the biocompatibility of bacterial cellulose |
Autor(es): | Andrade, Fábia K. Alexandre, Nuno Amorim, Irina Gartner, Fátima Maurício, Ana Colette Luís, Ana Lúcia Gama, Miguel |
Palavras-chave: | Bacterial cellulose Bacterial cellulose biocompatibility Tissue engineering Cell adhesion Mechanical properties Adhesion peptide Arg-Gly-Asp Arteries and veins |
Data: | 2013 |
Editora: | SAGE |
Revista: | Journal of bioactive and compatible polymers |
Resumo(s): | Bacterial cellulose was functionalized with a chimeric protein containing a cellulose-binding module and the adhesion peptide Arg-Gly-Asp. Small-diameter bacterial cellulose membranes were produced and subcutaneously implanted in sheep for 1–32 weeks. The implants triggered a biological response similar to other high surface-to-volume implants. There were no significant differences in the inflammation degree between the bacterial cellulose coated with the recombinant protein Arg-Gly-Asp–cellulose-binding module and the native bacterial cellulose. The implants were considered to be mildly irritating to the tissue compared to the negative control sample (expanded polytetrafluoroethylene). The analysis of the fluorescence microscopy revealed that, apart from increasing cell adhesion, the presence of Arg-Gly-Asp stimulated an even cell distribution, while the cells on the untreated bacterial cellulose seemed to form aggregates. Furthermore, the cells on the Arg-Gly-Asp–treated bacterial cellulose presented a more elongated morphology. Mechanical tests indicated that the small-diameter bacterial cellulose tubes were more elastic than the human arteries and veins. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/27317 |
DOI: | 10.1177/0883911512467643 |
ISSN: | 0883-9115 |
e-ISSN: | 1530-8030 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Studies on the biocompatibility of BC.pdf Acesso restrito! | 2,15 MB | Adobe PDF | Ver/Abrir |