Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/29335
Título: | Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H₂O₂ and superoxide dismutase activity |
Autor(es): | Mesquita, Ana Maria Macedo Weinberger, Martin Silva, Alexandra Marques, Belém Sampaio Almeida, Bruno Leão, Cecília Costa, Vitor Rodrigues, Fernando José dos Santos Burhans, William C. Ludovico, Paula |
Palavras-chave: | Aging Hydrogen peroxide Hormesis Antioxidant enzymes Oxidative oxidative damage |
Data: | 2010 |
Editora: | National Center for Biotechnology Information |
Revista: | Proceedings of the National Academy of Sciences |
Resumo(s): | The free radical theory of aging posits oxidative damage to macromolecules as a primary determinant of lifespan. Recent studies challenge this theory by demonstrating that in some cases, longevity is enhanced by inactivation of oxidative stress defenses or is correlated with increased, rather than decreased reactive oxygen species and oxidative damage. Here we show that, in Saccharomyces cerevisiae, caloric restriction or inactivation of catalases extends chronological lifespan by inducing elevated levels of the reactive oxygen species hydrogen peroxide, which activate superoxide dismutases that inhibit the accumulation of superoxide anions. Increased hydrogen peroxide in catalase-deficient cells extends chronological lifespan despite parallel increases in oxidative damage. These findings establish a role for hormesis effects of hydrogen peroxide in promoting longevity that have broad implications for understanding aging and age-related diseases. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/29335 |
DOI: | 10.1073/pnas.1004432107 |
ISSN: | 0027-8424 |
Versão da editora: | http://www.pnas.org/content/107/34/15123 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
mesquita a_ proc nat acad sci usa 2010 posp.pdf | 585,97 kB | Adobe PDF | Ver/Abrir |