Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/31639
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Francisco, Carla Santana | por |
dc.contributor.author | Rodrigues, L. R. | por |
dc.contributor.author | Cerqueira, N. M. F. S. A. | por |
dc.contributor.author | Campos, Ana M. F. Oliveira | por |
dc.contributor.author | Esteves, Ana Paula | por |
dc.date.accessioned | 2014-12-04T17:21:07Z | - |
dc.date.available | 2014-12-04T17:21:07Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Francisco, Carla S.; Rodrigues, L. R.; Cerqueira, Nuno M. F. S. A.; Oliveira-Campos, Ana M. F.; Esteves, Ana P., Novel benzopsoralen analogues: Synthesis, biological activity and molecular docking studies. European Journal of Medicinal Chemistry, 87, 298-305, 2014 | por |
dc.identifier.issn | 0223-5234 | por |
dc.identifier.uri | https://hdl.handle.net/1822/31639 | - |
dc.description.abstract | New benzopsoralen analogues were synthesized and their inhibitory effect on the growth of tumourtumour cell lines (MDA MB231 and TCC-SUP) was evaluated. The in vitro antitumour activity of the new benzopsoralen analogues was discussed in terms of structure–activity relationship. Molecular docking studies with human-CYP2A6 enzymes were also carried out with the synthesized compounds to evaluate the potential of these molecules to interact with the haem group of the enzymes. The results demonstrated that the compounds that are able to interact with the iron ion of the haem cofactor and at the same time with active site Asn297 are those that have better anti-proliferative activity. | por |
dc.description.sponsorship | To the Foundation for the Science and Technology (FCT, Portugal) for financial support to the NMR Portuguese network (PTNMR, Bruker Avance III 400-Univ. Minho). FCT and FEDER (European Fund for Regional Development)-COMPETE-QREN-EU for financial support to the Chemistry Research Centre, CQ/UM [PEst-C/QUI/UI0686/2011 (FCOMP-01-0124-FEDER-022716)], to REQUIMTE (PEst-C/EQB/LA0006/2011), to the Centre of Biological Engineering (PEst-OE/EQB/LA0023/2013) and the PhD grant to C.S.F. (SFRH/BD/48636/2008). The authors also acknowledge the Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP, Porto, Portugal) for kindly providing the breast cancer cell lines used in this work. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier B.V. | por |
dc.rights | openAccess | por |
dc.subject | Benzopsoralen analogues | por |
dc.subject | Antitumour activity | por |
dc.subject | Computational studies | por |
dc.subject | Molecular docking | por |
dc.title | Novel benzopsoralen analogues : synthesis, biological activity and molecular docking studies | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.comments | CEB18126 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 298 | por |
oaire.citationEndPage | 305 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationTitle | European Journal of Medicinal Chemistry | por |
oaire.citationVolume | 87 | por |
dc.date.updated | 2014-11-28T17:43:49Z | - |
dc.identifier.doi | 10.1016/j.ejmech.2014.09.066 | por |
dc.identifier.pmid | 25262050 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | European Journal of Medicinal Chemistry | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_18126_1.pdf | 971,59 kB | Adobe PDF | Ver/Abrir |