Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/32834
Título: | Polymorphism of Interleukin-6 is not associated with the presence or absence of high HPV E6/E7 |
Autor(es): | Longatto Filho, Adhemar Porto, Claudia Regina Cinti Kleine, João Paulo Ferreira de Oliveira Silva, Ismael Dale Cotrim Guerreiro da |
Palavras-chave: | Gene polymorphism IL6 HPV E6/E7 |
Data: | 2014 |
Editora: | International Institute of Anticancer Research (IIAR) |
Revista: | Anticancer Research |
Resumo(s): | The present study evaluated the frequency of the polymorphism of Interleukin-6 (IL6) in women positive for E6/E7 Human Papillomavirus (HPV) (n=152) and women negative for HPV (n=238), 390 women in total. Material for analysis was obtained at the Federal University of São Paulo. Interleukin-6 polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and analyzed in 3% agarose gel. RESULTS: No significant associations between the frequency of the polymorphism of IL6 in patients expressing E6 and E7 with HPV-positive and -negative reactions were found. There was no statistically significant difference between the case and control group for genotype distribution (p=0.280). CONCLUSION: Genotypic analysis showed a striking similarity of IL6 polymorphisms in both cases and controls. The allelic distribution in cases and controls for G and C of IL6 were very similar (p=0.186), which could point to similar IL6 functionality for both groups. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/32834 |
ISSN: | 0250-7005 |
Versão da editora: | http://ar.iiarjournals.org/content/34/7/3501.abstract |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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porto cr_ anticancer res 2014.pdf | 98,85 kB | Adobe PDF | Ver/Abrir |