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https://hdl.handle.net/1822/32990
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Campo DC | Valor | Idioma |
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dc.contributor.author | Correia, Hélder | por |
dc.contributor.author | Ramos, Patrícia | por |
dc.contributor.author | Santos, Agostinho | por |
dc.contributor.author | Pinto, Nair Rosas | por |
dc.contributor.author | Mendes, Ricardo | por |
dc.contributor.author | Magalhães, Teresa | por |
dc.contributor.author | Almeida, Agostinho | por |
dc.date.accessioned | 2015-01-19T17:26:45Z | - |
dc.date.available | 2015-01-19T17:26:45Z | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 0026-265X | por |
dc.identifier.uri | https://hdl.handle.net/1822/32990 | - |
dc.description.abstract | Calcium and magnesium levels in 14 different areas of the human brain [frontal cortex, superior and middle temporal gyri, caudate nucleus, putamen, globus pallidus, cingulated gyrus, hippocampus, inferior parietal lobule, visual cortex of the occipital lobe, midbrain, pons-locus coeruleus, medulla and cerebellum-dentate nucleus] of adult individuals (n = 42; 71 +/- 12, range: 50-103 years old) without a known history of neurodegenerative, neurological or psychiatric disorder were studied. Considering the mean values for the 14 regions, Mg was present at ca. 2.3-fold higher levels than Ca (mean +/-: 527 +/- 34 mu g/g versus 226 +/- 53 mu g/g). Calcium distribution within the brain showed to be quite heterogeneous: highest levels were found in the occipital (306 +/- 156 mu g/g) and frontal cortex (287 +/- 78 ug/g), while lowest levels were found in the medulla (186 +/- 70 mu g/g) and cerebellum (145 +/- 42 mu g/g). Higher Ca levels were found in women than in men (248 +/- 59 mu g/g versus 213 +/- 46 mu g/g; p < 0.05). A tendency for Ca levels to increase with age in all studied brain regions and in both genders was also observed. On the contrary, Mg presented a highly homogeneous distribution and seems to remain quite unchanged irrespective of aging. | por |
dc.description.sponsorship | The authors thank to Universidade do Porto and Santander Totta for financial support through the project "TRAIN: Trace elements in human brain: age-related changes and anatomic region specific differences" (PP_IJUP 2011 342). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | openAccess | por |
dc.subject | Human brain | por |
dc.subject | Calcium | por |
dc.subject | Magnesium | por |
dc.subject | Aging | por |
dc.subject | Post-mortem analysis | por |
dc.title | A post-mortem study of the anatomical region differences and age-related changes on Ca and Mg levels in the human brain | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.elsevier.com | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 69 | por |
oaire.citationEndPage | 76 | por |
oaire.citationTitle | Microchemical Journal | por |
oaire.citationVolume | 113 | por |
dc.date.updated | 2015-01-19T16:19:20Z | - |
dc.identifier.doi | 10.1016/j.microc.2013.11.012 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Microchemical Journal | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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correia h_microchem j 2014 prep.pdf | 685,83 kB | Adobe PDF | Ver/Abrir |