Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/35371
Título: | Surface roughness dependent osteoblast and fibroblast response on poly(l-lactide) films and electrospun membranes |
Autor(es): | Ribeiro, Clarisse Sencadas, Vítor João Gomes Silva Areias, Anabela C. Gama, F. M. Lanceros-Méndez, S. |
Palavras-chave: | poly(l-lactic acid) tissue and biomedical engineering cell-material interface |
Data: | Jul-2015 |
Editora: | John Wiley and Sons |
Revista: | Journal of Biomedical Materials Research: Part A |
Citação: | Ribeiro, Clarisse; Sencadas, Vitor; Areias, Anabela C.; Gama, F. M.; Lanceros-Méndez, Senentxu, Surface roughness dependent osteoblast and fibroblast response on poly(l-lactide) films and electrospun membranes. Journal of Biomedical Materials Research - Part A, 103(7), 2260-2268, 2015 |
Resumo(s): | Poly(l-lactide) electrospun mats with random and aligned fiber orientation and films have been produced with degrees of crystallinity ranging from 0 up to nearly 50%. The overall surface roughness is practically constant irrespective of the sampling areas (1 × 1 µm to 20 × 20 µm) for degrees of crystallinity below 30%, increasing for higher degrees of crystallinity for the larger sampling areas. Further, due to fiber confinement, surface roughness variations are smaller in electrospun mats. Samples with 50% of crystallinity show the lowest osteoblast and the highest fibroblast proliferation. Therefore, it is verified that higher roughness promotes lower osteoblast but higher fibroblast proliferation. The overall results indicate the relevant role of the sub-microenvironment variations associated to the microscale roughness in determining the different cell responses. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/35371 |
DOI: | 10.1002/jbm.a.35367 |
ISSN: | 1549-3296 1552-4965 |
e-ISSN: | 1549-3296 |
Versão da editora: | http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.35367/abstract;jsessionid=8A2C1C03714C3DDC3CA6D37F61DF5247.f01t03 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_18510_1.pdf | 582,6 kB | Adobe PDF | Ver/Abrir |