Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/37845
Título: | Magnetic Liposomes based on Nickel Ferrite Nanoparticles for biomedical applications |
Autor(es): | Rodrigues, Ana Rita O. Gomes, I. Tarroso Almeida, B. G. Araújo, João P. Castanheira, Elisabete M. S. Coutinho, Paulo J. G. |
Palavras-chave: | Magnetic nanoparticles Cancer therapy Liposomes Drug nanocarriers |
Data: | Jun-2015 |
Editora: | Royal Society of Chemistry |
Revista: | Physical Chemistry Chemical Physics |
Resumo(s): | Nickel ferrite nanoparticles with superparamagnetic behavior at room temperature were synthesized by a coprecipitation method. These magnetic nanoparticles were either covered with a lipid bilayer, forming dry magnetic liposomes (DMLs), or entrapped in liposomes, originating aqueous magnetoliposomes (AMLs). A new and promising method for the synthesis of DMLs is described. The presence of the lipid bilayer in DMLs was confirmed by FRET (Förster Resonance Energy Transfer) measurements between the fluorescent-labeled lipids NBD-C12-HPC (NBD acting as donor) included in the second lipid layer and rhodamine B-DOPE (acceptor) in the first lipid layer. An average donor-acceptor distance of 3 nm was estimated. Assays of the non-specific interactions of magnetoliposomes with biological membranes (modeled using giant unilamellar vesicles, GUVs) were performed. Membrane fusion between both aqueous and dry magnetoliposomes and GUVs was confirmed by FRET, which is an important result regarding applications of these systems both as hyperthermia agents and antitumor drug nanocarriers. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/37845 |
DOI: | 10.1039/C5CP01894C |
ISSN: | 1463-9076 1463-9084 |
Versão da editora: | The original publication is available at: http://pubs.rsc.org/en/content/articlehtml/2015/cp/c5cp01894c |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDF - FAMO - Artigos/Papers (with refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Magnetoliposomes_paper_revised.pdf Acesso restrito! | Documento principal | 1,69 MB | Adobe PDF | Ver/Abrir |
Magnetic Liposomes based on Nickel Ferrite_Supplementary_Information.pdf Acesso restrito! | Informação Suplementar | 516,65 kB | Adobe PDF | Ver/Abrir |