Self-assembled hyaluronic acid nanoparticles: effect of molecular weight and two different chemical approaches

Abstract

INTRODUCTION: Natural polyssacharides, such as hyaluronic acid (HyA) have been widely used for biomedical and pharmaceutical applications. Hya has multiple functional groups available for chemical conjugation that can convert HyA into nano-sized carriers. We prepared self-assembled HyA nanoparticles by two different chemical derivatization techniques and used two different molecular weights HyA. Our aim was to compare these two techniques and evaluate the influence of molecular weight in the properties of HyA nanoparticles. (...)