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https://hdl.handle.net/1822/40084
Título: | NF-kB pathway controls mitochondrial dynamics |
Autor(es): | Laforge, M. Rodrigues, Vasco Silvestre, Ricardo Jorge Leal Gautier, C. Weil, R. Corti, O. Estaquier, J. |
Data: | 2016 |
Editora: | Nature Publishing Group |
Revista: | Cell Death and Differentiation |
Citação: | Laforge, M., Rodrigues, V., Silvestre, R., Gautier, C., Weil, R., Corti, O., & Estaquier, J. (2016). NF-kappa B pathway controls mitochondrial dynamics. Cell Death and Differentiation, 23(1), 89-98. doi: 10.1038/cdd.2015.42 |
Resumo(s): | The Optic atrophy 1 protein (OPA1) is a key element in the dynamics and morphology of mitochondria. We demonstrated that the absence of I?B kinase-a, which is a key element of the nonclassical NF-?B pathway, has an impact on the mitochondrial network morphology and OPA1 expression. In contrast, the absence of NF-?B essential modulator (NEMO) or I?B kinase-ß, both of which are essential for the canonical NF-?B pathway, has no impact on mitochondrial dynamics. Whereas Parkin has been reported to positively regulate the expression of OPA1 through NEMO, herein we found that PARK2 overexpression did not modify the expression of OPA1. PARK2 expression reduced the levels of Bax, and it prevented stress-induced cell death only in Bak-deficient mouse embryonic fibroblast cells. Collectively, our results point out a role of the nonclassical NF-?B pathway in the regulation of mitochondrial dynamics and OPA1 expression. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/40084 |
DOI: | 10.1038/cdd.2015.42 |
ISSN: | 2041-4889 |
Versão da editora: | http://www.nature.com/cddis/index.html |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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laforge et al_final.pdf | 3,45 MB | Adobe PDF | Ver/Abrir |