Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/41029
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Campo DC | Valor | Idioma |
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dc.contributor.author | Bockmühl, Yvonne | por |
dc.contributor.author | Patchev, Alexandre V. | por |
dc.contributor.author | Madejska, Arleta | por |
dc.contributor.author | Hoffmann, Anke | por |
dc.contributor.author | Sousa, João Carlos | por |
dc.contributor.author | Sousa, Nuno | por |
dc.contributor.author | Holsboer, Florian | por |
dc.contributor.author | Almeida, Osborne F. X. | por |
dc.contributor.author | Spengler, Dietmar | por |
dc.date.accessioned | 2016-04-06T11:36:01Z | - |
dc.date.available | 2016-04-06T11:36:01Z | - |
dc.date.issued | 2015-03 | - |
dc.date.submitted | 2014-11 | - |
dc.identifier.citation | Bockmühl, Y., Patchev, A. V., Madejska, A., Hoffmann, A., Sousa, J. C., Sousa, N., et. al.(2015). Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress. Epigenetics, 10(3), 247-257 | por |
dc.identifier.issn | 1559-2294 | por |
dc.identifier.uri | https://hdl.handle.net/1822/41029 | - |
dc.description.abstract | Early-life stress (ELS) induces long-lasting changes in gene expression conferring an increased risk for the development of stress-related mental disorders. Glucocorticoid receptors (GR) mediate the negative feedback actions of glucocorticoids (GC) in the paraventricular nucleus (PVN) of the hypothalamus and anterior pituitary and therefore play a key role in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and the endocrine response to stress. We here show that ELS programs the expression of the GR gene (Nr3c1) by site-specific hypermethylation at the CpG island (CGI) shore in hypothalamic neurons that produce corticotropin-releasing hormone (Crh), thus preventing Crh upregulation under conditions of chronic stress. CpGs mapping to the Nr3c1 CGI shore region are dynamically regulated by ELS and underpin methylation-sensitive control of this region's insulation-like function via Ying Yang 1 (YY1) binding. Our results provide new insight into how a genomic element integrates experience-dependent epigenetic programming of the composite proximal Nr3c1 promoter, and assigns an insulating role to the CGI shore. | por |
dc.description.sponsorship | European Union Directorate General for Research & Innovation through the CRESCENDO Consortium (O.F.X.A. and D.S) and the NINA Initial Training Program (D.S. and O.F.X.A) | por |
dc.language.iso | eng | por |
dc.publisher | Taylor and Francis | por |
dc.rights | openAccess | por |
dc.subject | CpG island shore | por |
dc.subject | DNA methylation | por |
dc.subject | Early-life stress | por |
dc.subject | Glucocorticoid receptor | por |
dc.subject | Insulator | por |
dc.subject | Yin Yang | por |
dc.title | Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.tandfonline.com/doi/abs/10.1080/15592294.2015.1017199 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 247 | por |
oaire.citationEndPage | 257 | por |
oaire.citationIssue | 3 | por |
oaire.citationTitle | Epigenetics | por |
oaire.citationVolume | 10 | por |
dc.date.updated | 2016-03-07T13:09:28Z | - |
dc.identifier.doi | 10.1080/15592294.2015.1017199 | por |
dc.identifier.pmid | 25793778 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Epigenetics | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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bockmuhl et al, 2015.pdf | 783,5 kB | Adobe PDF | Ver/Abrir |