Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/41573
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Pereira, P. | por |
dc.contributor.author | Rosa, S. C. | por |
dc.contributor.author | Praça, C. | por |
dc.contributor.author | Ferreira, L. | por |
dc.date.accessioned | 2016-05-12T13:51:43Z | - |
dc.date.available | 2016-05-12T13:51:43Z | - |
dc.date.issued | 2016-05-06 | - |
dc.identifier.citation | Pereira, P.; Rosa, S. C.; Praça, C.; Ferreira, L., Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome. Biochemical and Biophysical Research Communications, 473(3), 710-718, 2016 | por |
dc.identifier.issn | 0006-291X | por |
dc.identifier.uri | https://hdl.handle.net/1822/41573 | - |
dc.description | Transparency document related to this article can be found online at http://dx.doi.org/10.1016/j.bbrc.2015.10.014 | - |
dc.description.abstract | Induced pluripotent stem cells (iPSCs) represent today an invaluable tool to create disease cell models for modeling and drug screening. Several lines of iPSCs have been generated in the last 7 years that changed the paradigm for studying diseases and the discovery of new drugs to treat them. In this article we focus our attention to vascular diseases in particular Hutchinson-Gilford Progeria Syndrome (HGPS), a devastating premature aging disease caused by a mutation in the lamin A gene. In general, patients die because of myocardial infarction or stroke. Because the patients are fragile the isolation of a particular type of cells is very difficult. Therefore in the last 5 years, researchers have used cells derived from iPSCs to model aspects of the HGPS and to screen libraries of chemicals to retard or treat the disease. | por |
dc.description.sponsorship | This work was supported by Fundação para a Ciência e a Tecnologia (PTDC/SAU-TOX/121887/2010; SFRH/BD/71042/2010; SFRH/BD/51678/2011; SFRH/BPD/79323/2011) and COMPETE funding (Project “Stem cell based platforms for Regenerative and Therapeutic Medicine”, Centro-07-ST24-FEDER-002008). The authors declare no conflict of interest to disclose. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/121887/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/121887/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F71042%2F2010/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F51678%2F2011/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F79323%2F2011/PT | por |
dc.rights | openAccess | por |
dc.subject | Vascular cells | por |
dc.subject | Induced pluripotent stem cells | por |
dc.subject | Progeria disease | por |
dc.subject | Drug modeling | por |
dc.subject | Drug screening | por |
dc.title | Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.elsevier.com/locate/issn/0006291X | por |
dc.comments | CEB23439 | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 710 | por |
oaire.citationEndPage | 718 | por |
oaire.citationIssue | 3 | por |
oaire.citationConferencePlace | United States | - |
oaire.citationTitle | Biochemical and Biophysical Research Communications | por |
oaire.citationVolume | 473 | por |
dc.date.updated | 2016-05-02T09:23:04Z | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.doi | 10.1016/j.bbrc.2015.10.014 | por |
dc.identifier.pmid | 26474704 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biochemical and Biophysical Research Communications | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_23439_1.pdf | 1,03 MB | Adobe PDF | Ver/Abrir |