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https://hdl.handle.net/1822/42448
Título: | Preliminary studies on the susceptibility of Staphylococcus epidermidis biofilm-released cells to antibiotics and ability to survive in the presence of human blood |
Autor(es): | Gaio, Vânia Gonçalves, Vanessa Acúrcio França, Ângela Maria Oliveira Sousa Cerca, Nuno |
Data: | 26-Jun-2016 |
Citação: | Gaio, V.; Acúrcio, V.; França, Angela; Cerca N, Preliminary studies on the susceptibility of Staphylococcus epidermidis biofilm-released cells to antibiotics and ability to survive in the presence of human blood. Biofilms 7 - Microbial Works of Art. No. P3: 83, Porto, Portugal, June 26-28, 2016. ISBN: 978-989-97478-7-6 |
Resumo(s): | Worldwide, the formation of bacterial biofilms on the surface of medical devices is a major concern in health care systems due to their high tolerance to antibiotics and ability to evade the host immune system. Biofilm lifecycle involves three stages: 1) adhesion, 2) accumulation and maturation and 3) biofilm disassembly. Biofilm disassembly, in which cells from the biofilm are released to other sites, is thought to be one of the major causes of the emergence of serious complications such as sepsis and embolic events of endocarditis, as observed in S. epidermidis biofilm infections. Despite the clinical relevance of these cells, little is known about the phenotypic changes that occur after being released from the biofilm. To overcome this lack of knowledge, we performed a series of in vitro assays aiming to compare the susceptibility of planktonic, biofilms and biofilm-released cells to several antibiotics. In addition, the ability of these populations to evade circulating immune cells was also addressed. Interestingly, our results showed that biofilm-released cells presented a different phenotype when exposed to some antibiotics. However, regarding the ability to evade the circulating immune cells, no significant differences among the distinct populations were observed. Thus, these findings indicate that biofilm-released cells present a distinct antimicrobial tolerance that should be investigated in depth, in order to proficiently target, prevent and treat S. epidermidis biofilm-related infections. |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/42448 |
ISBN: | 978-989-97478-7-6 |
Versão da editora: | https://biofilms7.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_40138_1.pdf | 165,33 kB | Adobe PDF | Ver/Abrir |