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https://hdl.handle.net/1822/42479
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Campo DC | Valor | Idioma |
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dc.contributor.author | Agnello, Stefano | por |
dc.contributor.author | Gasperini, Luca | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Mano, J. F. | por |
dc.contributor.author | Pitarresi, Giovanna | por |
dc.contributor.author | Palumbo, Fabio S. | por |
dc.contributor.author | Giammona, Gaetano | por |
dc.date.accessioned | 2016-09-07T10:16:55Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Agnello S., Gasperini L., Reis R. L., Mano J. F., Pitarresi G., Palumbo F. S., Giammona G. Microfluidic production of hyaluronic acid derivative microfibers to control drug release, Materials Letters, Vol. 182, pp. 309-313, doi:10.1016/j.matlet.2016.07.014, 2016 | por |
dc.identifier.issn | 0167-577X | por |
dc.identifier.uri | https://hdl.handle.net/1822/42479 | - |
dc.description | "Available online 4 July 2016" | por |
dc.description.abstract | Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability oMicrofibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.f the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications. | por |
dc.description.sponsorship | This work was supported by European Research Council Grant agreement ERC-2012-ADG 20120216-321266 for project ComplexiTE. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/321266/EU | por |
dc.rights | restrictedAccess | por |
dc.subject | Biomaterials | por |
dc.subject | Polymers | por |
dc.subject | Hyaluronic acid | por |
dc.subject | Microfibers | por |
dc.subject | Microfluidic technique | por |
dc.subject | Polymers | por |
dc.subject | Drug delivery | por |
dc.title | Microfluidic production of hyaluronic acid derivative microfibers to control drug release | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0167577X16311089 | por |
dc.comments | http://3bs.uminho.pt/node/18794 | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 309 | por |
oaire.citationEndPage | 313 | por |
oaire.citationTitle | Materials Letters | por |
oaire.citationVolume | 182 | por |
dc.date.updated | 2016-09-05T15:47:54Z | - |
dc.identifier.doi | 10.1016/j.matlet.2016.07.014 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Materials Letters | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
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