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https://hdl.handle.net/1822/44402
Título: | Osteochondral tissue engineering and regenerative strategies |
Autor(es): | Canadas, Raphael Faustino Marques, A. P. Reis, R. L. Oliveira, J. M. |
Palavras-chave: | Bilayer Biodegradable Material Biomaterial Bioreactor Bone Cartilage Cell therapy Ceramic Hydrogel In Vitro Model Injectable material Osteochondral Polymer Regenerative medicine Scaffold Stem cells Tissue engineering Articular Cartilage Articular Chondrocytes Autologous Chondrocytes Implantation Hyaluronic Acid Subchondral Bone |
Data: | 2017 |
Editora: | Springer International Publishing AG |
Revista: | Studies in Mechanobiology Tissue Engineering and Biomaterials |
Citação: | Canadas R. F., Marques A. P., Reis R. L., Oliveira J. M. Osteochondral Tissue Engineering and Regenerative Strategies, Regenerative Strategies for the Treatment of Knee Joint Disabilities, Vol. 21, pp. 213-233, doi:10.1007/978-3-319-44785-8_11, 2016 |
Resumo(s): | The orthopedic field has been facing challenging difficulties when it comes to regeneration of large and/or complex defects as we come across in osteochondral (OC) cases of lesions grade 4. Autologous OC mosaicplasty has proven to be a valid therapeutic option but donor site morbidity and the lack of long-term functionality remain sources of concern. OC tissue engineering has shown an increasing development to provide suitable strategies for the regeneration of damaged cartilage and underlying subchondral bone tissue. The use of two scaffolds with optimized properties for bone and cartilage architectures combined at the time of implantation as a multilayered structure was one of the first approaches for OC large defects regeneration. Last decade strategies using a bony-like scaffold supporting a cell layer for cartilage phase were introduced. Beyond the approaches already mentioned, three other strategies were reported for OCD regeneration. One methodology was the use of two different layers with a compact interface to create an integrated bilayered scaffold before cell seeding. A second strategy was the use of a single continuous structure but with different features in each layer. The last one was the combination of hydrogel phases creating this way the possibility to have injectable systems. These promising strategies for the regeneration of complex OCDs comprise the use of different biomaterials, growth factors, and cells alone or in combination, but the ideal solution is still to be found. The interface’s mechanical properties have to be optimized. A different problem is related with the cell culture method within the 3D bilayered structures with heterogeneous properties. With the increasing demand of these stratified 3D structures new cell culture systems are required. Moreover these structures present the potential to be used as in vitro models, which is a need also because of the pressure resulting from the 3R’s principle implementation that is now occurring. Regarding this, adapted bioreactors are being developed, but more efforts are required to target this scientific demand. |
Tipo: | Capítulo de livro |
Descrição: | Series: Studies in mechanobiology, tissue engineering and biomaterials, ISSN 1868-2006, vol. 21 |
URI: | https://hdl.handle.net/1822/44402 |
ISBN: | 978-3-319-44783-4 |
e-ISBN: | 978-3-319-44785-8 |
DOI: | 10.1007/978-3-319-44785-8_11 |
ISSN: | 1868-2006 |
Acesso: | Acesso restrito UMinho |
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Ficheiro | Descrição | Tamanho | Formato | |
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18402-Chapter 11_Osteochondral Tissue Engineering and Regenerative Strategies.pdf Acesso restrito! | 550,51 kB | Adobe PDF | Ver/Abrir |