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https://hdl.handle.net/1822/44868
Título: | Longitudinal evaluation of regulatory T-cell dynamics on HIV-infected individuals during the first 2 years of therapy |
Autor(es): | Nobrega, Claudia Horta, Ana Maria Lacerda Morgado Fernandes Carvalho Aboim Teixeira, Vítor Emanuel Coutinho Martins-Ribeiro, Ana Silva, Rita Catarina Assunção Ribeiro Santos, Catarina Lopes Castro, Rui Manuel Rosário Sarmento Neves, Margarida Correia |
Palavras-chave: | Antiretroviral therapy Baseline CD4+ T-cell counts HIV Immune reconstitution Regulatory T cells |
Data: | Mai-2016 |
Editora: | Lippincott, Williams & Wilkins |
Revista: | AIDS |
Citação: | Nobrega, C., Horta, A., Coutinho-Teixeira, V., Martins-Ribeiro, A., Baldaia, A., Rb-Silva, R., ... & Correia-Neves, M. (2016). Longitudinal evaluation of regulatory T-cell dynamics on HIV-infected individuals during the first 2 years of therapy. AIDS (London, England), 30(8), 1175. doi: 10.1097/QAD.0000000000001074 |
Resumo(s): | Objectives: A sizeable percentage of individuals infected by HIV and on antiretroviral therapy (ART) fail to increase their CD4+ T-cells to satisfactory levels. The percentage of regulatory T-cells (Tregs) has been suggested to contribute to this impairment. This study aimed to address this question and to expand the analysis of Tregs subpopulations during ART. Design: Longitudinal follow-up of 81 HIV-infected individuals during the first 24 months on ART. Methods: CD4+ T-cell counts, Tregs percentages, and specific Tregs subpopulations were evaluated at ART onset, 2, 6, 9, 12, 16, 20, and 24 months of ART (five individuals had no Tregs information at baseline). Results: The slope of CD4+ T-cell recovery was similar for individuals with moderate and with severe lymphopenia at ART onset. No evidence was found for a contribution of the baseline Tregs percentages on the CD4+ T-cell counts recovery throughout ART. In comparison to uninfected individuals, Tregs percentages were higher at ART onset only for patients with less than 200?cells/µl at baseline and decreased afterwards reaching normal values. Within Tregs, the percentage of naive cells remained low in these patients. Reduced thymic export and increased proliferation of Tregs vs. conventional CD4+ T cells might explain these persistent alterations. Conclusion: No effect of Tregs percentages at baseline was detected on CD4+ T-cell recovery. However, profound alterations on Tregs subpopulations were consistently observed throughout ART for patients with severe lymphopenia at ART onset. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/44868 |
DOI: | 10.1097/QAD.0000000000001074 |
ISSN: | 1473-5571 |
Versão da editora: | http://journals.lww.com/aidsonline/Pages/default.aspx |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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aids-30-1175.pdf | 1,5 MB | Adobe PDF | Ver/Abrir |