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https://hdl.handle.net/1822/48493| Título: | The influence of copolymer composition on PLGA/nHA scaffolds´ cytotoxicity and in vitro degradation |
| Autor(es): | Díaz, E. Puerto, I. Ribeiro, Sylvie Oliveira Lanceros-Méndez, S. Barandiarán, J. M. |
| Palavras-chave: | Scaffolds PLGA nHA Cytotoxicity In vitro degradation |
| Data: | Jul-2017 |
| Editora: | MDPI |
| Revista: | Nanomaterials |
| Citação: | Díaz, E., Puerto, I., Ribeiro, S., Lanceros-Mendez, S., & Barandiarán, J. M. (2017). The Influence of Copolymer Composition on PLGA/nHA Scaffolds’ Cytotoxicity and In Vitro Degradation. Nanomaterials, 7(7), 173 |
| Resumo(s): | The influence of copolymer composition on Poly(Lactide-co-Glycolide)/ nanohydroxyapatite (PLGA/nHA) composite scaffolds is studied in the context of bone tissue engineering and regenerative medicine. The composite scaffolds are fabricated by thermally-induced phase separation and the effect of bioactive nanoparticles on their in vitro degradation in phosphate-buffered solution at 37 °C is analyzed over eight weeks. The indirect cytotoxicity evaluation of the samples followed an adaptation of the ISO 10993-5 standard test method. Based on the measurement of their molecular weight, molar mass, pH, water absorption and dimensions, the porous scaffolds of PLGA with a lower lactide/glycolide (LA/GA) molar ratio degraded faster due to their higher hydrophilicity. All of the samples without and with HA are not cytotoxic, demonstrating their potential for tissue engineering applications. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/48493 |
| DOI: | 10.3390/nano7070173 |
| ISSN: | 2079-4991 |
| e-ISSN: | 2079-4991 |
| Versão da editora: | http://www.mdpi.com/2079-4991/7/7/173/htm |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: | CDF - FCD - Artigos/Papers (with refereeing) |
