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https://hdl.handle.net/1822/49053
Título: | CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? |
Autor(es): | Moukambi, Félicien Rodrigues, Vasco Fortier, Yasmina Rabezanahary, Henintsoa Borde, Chloé Krust, Bernard Andreani, Guadalupe Silvestre, Ricardo Jorge Leal Petrovas, Constantinos Laforge, Mireille Estaquier, Jérôme |
Palavras-chave: | AIDS Tfh CD4 B cell Vaccine Pathogen SIV Reservoir |
Data: | 20-Fev-2017 |
Editora: | Frontiers Media |
Revista: | Frontiers in Immunology |
Citação: | Moukambi, F., Rodrigues, V., Fortier, Y., Rabezanahary, H., Borde, C., Krust, B., et. al. (2017). CD4 T follicular helper cells and HIV infection: friends or enemies?. Frontiers in immunology, 8. |
Resumo(s): | Follicular T helper (Tfh) cells, a subset of CD4 T lymphocytes, are essential for memory B cell activation, survival, and differentiation and assist B cells in the production of antigen-specific antibodies. Work performed in recent years pointed out the importance of Tfh cells in the context of HIV and SIV infections. The importance of tissue distribution of Tfh is also an important point since their frequency differs between peripheral blood and lymph nodes compared to the spleen, the primary organ for B cell activation, and differentiation. Our recent observations indicated an early and profound loss of splenic Tfh cells. The role of transcriptional activator and repressor factors that control Tfh differentiation is also discussed in the context of HIV/SIV infection. Because Tfh cells are important for B cell differentiation and antibody production, accelerating the Tfh responses early during HIV/SIV infection could be promising as novel immunotherapeutic approach or alternative vaccine strategies. However, because Tfh cells are infected during the HIV/SIV infection and represent a reservoir, this may interfere with HIV vaccine strategy. Thus, Tfh represent the good and bad guys during HIV infection. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/49053 |
DOI: | 10.3389/fimmu.2017.00135 |
ISSN: | 1664-3224 |
Versão da editora: | https://www.frontiersin.org/articles/10.3389/fimmu.2017.00135/full |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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fimmu-08-00135.pdf | 1,34 MB | Adobe PDF | Ver/Abrir |