Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/50177
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Lima, Rui Augusto Ribeiro | por |
dc.contributor.author | Monteiro, Susana Isabel Gonçalves | por |
dc.contributor.author | Lopes, José Luís Pimenta | por |
dc.contributor.author | Barradas, Pedro | por |
dc.contributor.author | Vasconcelos, Natália L. | por |
dc.contributor.author | Gomes, Eduardo Domingos Correia | por |
dc.contributor.author | Silva, Rita Catarina Assunção Ribeiro | por |
dc.contributor.author | Teixeira, Fábio Gabriel Rodrigues | por |
dc.contributor.author | Morais, Mónica | por |
dc.contributor.author | Sousa, Nuno | por |
dc.contributor.author | Salgado, A. J. | por |
dc.contributor.author | Silva, Nuno André Martins | por |
dc.date.accessioned | 2018-02-07T17:33:16Z | - |
dc.date.available | 2018-02-07T17:33:16Z | - |
dc.date.issued | 2017-10-24 | - |
dc.identifier.citation | Lima, R., Monteiro, S., Lopes, J. P., et. al. (2017). Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection. Pharmaceuticals, 10(4), 83 | por |
dc.identifier.issn | 1424-8247 | - |
dc.identifier.uri | https://hdl.handle.net/1822/50177 | - |
dc.description.abstract | Traumatic spinal cord injury (SCI) causes dramatic disability and dysfunction in the motor, sensory and autonomic systems. The severe inflammatory reaction that occurs after SCI is strongly associated with further tissue damage. As such, immunomodulatory strategies have been developed, aimed at reducing inflammation, but also at shaping the immune response in order to protect, repair and promote regeneration of spared neural tissue. One of those promising strategies is the intraspinal administration of the cytokine interleukin-4 (IL-4) that was shown to promote a phenotype on specific immune cells associated with neuroprotection and repair. In this work, we evaluated if a systemic delivery of IL-4 for a 7-days period was also capable of promoting neuroprotection after SCI by analyzing different neural cells populations and motor recovery. IL-4 treatment promoted an elevation of the anti-inflammatory cytokine IL-10 in the serum both at 24 h and 7 days after injury. Locally, treatment with IL-4 led to a reduction on cells expressing markers associated with inflammation, CD11b/c and iNOS. Importantly, IL-4 treatment increased the neuronal markers beta III-tubulin and NeuN, and the oligodendrocyte marker O4, suggesting a neuroprotective effect. Moreover, 100% of the animals treated with IL-4 were able to recover weight support against only 33% of saline treated animals. Overall, these results show that systemic administration of IL-4 positively impacts different aspects of spinal cord injury, creating a more favorable environment for recovery to take place. | por |
dc.description.sponsorship | Prémios Santa Casa Neurociências—Prize Melo e Castro for Spinal Cord Injury Research; Portuguese Foundation for Science and Technology (Financiado no âmbito do Projecto 3599—Promover a Produção Científica e Desenvolvimento Tecnológico e a Constituição de Redes Temáticas (3599-PPCDT), project: PTDC/DTP-FTO/5109/2014; Post-Doctoral fellowship—SFRH/BPD/97701/2013—to N.A. Silva; IF Development Grant to A. J. Salgado; fellowships—PD/BDE/127836/2016—to R. Lima; SFRH/BD/103075/2014—to E. D. Gomes; PDE/BDE/113596/2015—to R. C. Assunção-Silva; SFRH/BD/88825/2012—to M. Morais); This article is a result of the project (NORTE-01-0145-FEDER-000013), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (FEDER); This work has been funded by FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-007038 | por |
dc.language.iso | eng | por |
dc.publisher | MDPI Publishing | por |
dc.rights | openAccess | por |
dc.subject | Spinal cord injury | por |
dc.subject | Neuroprotection | por |
dc.subject | Immunomodulation | por |
dc.subject | Interleukin-4 | por |
dc.subject | Neuroimmunology | por |
dc.title | Systemic interleukin-4 administration after spinal cord injury modulates inflammation and promotes neuroprotection | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.mdpi.com/1424-8247/10/4/83 | por |
oaire.citationIssue | 83 | por |
oaire.citationVolume | 10 | por |
dc.date.updated | 2018-01-15T14:54:43Z | - |
dc.identifier.doi | 10.3390/ph10040083 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Pharmaceuticals | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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r lima_pharmaceuticals_2017.pdf | 5,04 MB | Adobe PDF | Ver/Abrir |