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https://hdl.handle.net/1822/51034
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Campo DC | Valor | Idioma |
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dc.contributor.author | Simonyan, Lilit | por |
dc.contributor.author | Renault, Thibaud T. | por |
dc.contributor.author | Novais, Maria João da Costa | por |
dc.contributor.author | Sousa, Maria João | por |
dc.contributor.author | Côrte-Real, Manuela | por |
dc.contributor.author | Camougrand, Nadine | por |
dc.contributor.author | Gonzalez, Cécile | por |
dc.contributor.author | Manon, Stéphen | por |
dc.date.accessioned | 2018-02-26T11:23:04Z | - |
dc.date.issued | 2016-01-01 | - |
dc.identifier.citation | Simonyan, L., Renault, T. T., Costa Novais, M. J., Sousa, M. J., Côrte‐Real, M., Camougrand, N., ... & Manon, S. (2016). Regulation of Bax/mitochondria interaction by AKT. FEBS letters, 590(1), 13-21 | por |
dc.identifier.issn | 0014-5793 | por |
dc.identifier.uri | https://hdl.handle.net/1822/51034 | - |
dc.description.abstract | Bax-dependent mitochondrial permeabilization during apoptosis is controlled by multiple factors, including the phosphorylation by the protein kinase AKT. We used the heterologous co-expression of human Bax and AKT1 in yeast to investigate how the kinase modulates the different steps underlying Bax activation. We found that AKT activated Bax and increased its cellular content. Both effects were dependent on Ser184, but a phosphorylation of this residue did not fully explain the effects of AKT. Additional experiments with mutants substituted on Ser184 suggested that the regulation of Bax dynamic equilibrium between the cytosol and mitochondria might be more tightly regulated by Bcl-xL when Bax is phosphorylated. | por |
dc.description.sponsorship | - The authors wish to thank Dr Patrick Legembre (INSERM, Rennes) for the gift of AKT1 cDNA. This work was supported by grants from the Agence Nationale pour la Recherche (ANR project Phosbax, ANR-12-ISV8-0002), the Centre National de la Recherche Scientifique (CNRS) and the Fundacao para a Ciencia e a Tecnologia (FCT-ANR/BEX-BCM/0175/2012) and by FCT I.P. through the strategic funding UID/BIA/04050/2013. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.rights | restrictedAccess | por |
dc.subject | AKT | por |
dc.subject | Apoptosis | por |
dc.subject | Bcl-2 family | por |
dc.subject | Mitochondria | por |
dc.subject | Yeast model | por |
dc.title | Regulation of Bax/mitochondria interaction by AKT | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/1873-3468.12030/full | por |
oaire.citationStartPage | 13 | por |
oaire.citationEndPage | 21 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 590 | por |
dc.date.updated | 2018-02-23T17:51:51Z | - |
dc.identifier.eissn | 1873-3468 | por |
dc.identifier.doi | 10.1002/1873-3468.12030 | por |
dc.identifier.pmid | 26763134 | - |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | - |
sdum.export.identifier | 2932 | - |
sdum.journal | FEBS Letters | por |
Aparece nas coleções: | DBio - Artigos/Papers |
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Simonyan_et_al.pdf Acesso restrito! | 740,74 kB | Adobe PDF | Ver/Abrir |