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https://hdl.handle.net/1822/51342
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Campo DC | Valor | Idioma |
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dc.contributor.author | Almeida, Raquel Carvalho Ferreira Costa | por |
dc.contributor.author | Franco, Albina Ribeiro | por |
dc.contributor.author | Pesqueira, Tamagno | por |
dc.contributor.author | Oliveira, Mariana Braga | por |
dc.contributor.author | Babo, Pedro S. | por |
dc.contributor.author | Leonor, I. B. | por |
dc.contributor.author | Mano, J. F. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Gomes, Manuela E. | por |
dc.date.accessioned | 2018-03-01T15:10:09Z | - |
dc.date.issued | 2018-01-16 | - |
dc.identifier.citation | Costa-Almeida R., Franco A. R., Pesqueira T., Oliveira M. B., Babo P. S., Leonor I. B., Mano J. F., Reis R. L., Gomes M. E. The effects of platelet lysate patches on the activity of tendon-derived cells, Acta Biomaterialia, doi:10.1016/j.actbio.2018.01.006, 2018 | por |
dc.identifier.issn | 1742-7061 | por |
dc.identifier.uri | https://hdl.handle.net/1822/51342 | - |
dc.description.abstract | Platelet-derived biomaterials are widely explored as cost-effective sources of therapeutic factors, holding a strong potential for endogenous regenerative medicine. Particularly for tendon repair, treatment approaches that shift the injury environment are explored to accelerate tendon regeneration. Herein, genipin-crosslinked platelet lysate (PL) patches are proposed for the delivery of human-derived therapeutic factors in patch augmentation strategies aiming at tendon repair. Developed PL patches exhibited a controlled release profile of PL proteins, including bFGF and PDGF-BB. Additionally, PL patches exhibited an antibacterial effect by preventing the adhesion, proliferation and biofilm formation by S. aureus, a common pathogen in orthopaedic surgical site infections. Furthermore, these patches supported the activity of human tendon-derived cells (hTDCs). Cells were able to proliferate over time and an up-regulation of tenogenic genes (SCX, COL1A1 and TNC) was observed, suggesting that PL patches may modify the behavior of hTDCs. Accordingly, hTDCs deposited tendon-related extracellular matrix proteins, namely collagen type I and tenascin C. In summary, PL patches can act as a reservoir of biomolecules derived from PL and support the activity of native tendon cells, being proposed as bioinstructive patches for tendon regeneration. | por |
dc.description.sponsorship | Authors also acknowledge Portuguese funds through FCT – Fundação para a Ciência e a Tecnologia in the framework of FCT-POPH-FSE, the PhD grant SFRH/BD/96593/2013 of R.C-A, the postdoctoral grant SFRH/BPD/100760/2014 of A.R.F. and the consolidator grant IF/00593/2015 of M.E.G.; to the project RL3-TECT-NORTE-07-0124-FEDER000020 cofinanced by ON.2 under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF) and the European Research Council for the project ComplexiTE grant agreement ERC-2012- ADG 20120216-321266. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/321266/EU | por |
dc.rights | restrictedAccess | por |
dc.subject | Antibacterial efficacy | por |
dc.subject | Controlled release | por |
dc.subject | Endogenous regeneration | por |
dc.subject | Tenogenic genes | por |
dc.subject | Tendon patch | por |
dc.title | The effects of platelet lysate patches on the activity of tendon-derived cells | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1742706118300175 | por |
dc.comments | http://3bs.uminho.pt/node/19305 | por |
oaire.citationStartPage | 29 | por |
oaire.citationEndPage | 40 | por |
oaire.citationVolume | 68 | por |
dc.date.updated | 2018-02-09T17:20:12Z | - |
dc.identifier.eissn | 1878-7568 | por |
dc.identifier.doi | 10.1016/j.actbio.2018.01.006 | por |
dc.identifier.pmid | 29341933 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Acta Biomaterialia | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19305-Costa-Almeida et al 2018_Acta Bio.pdf Acesso restrito! | 1,49 MB | Adobe PDF | Ver/Abrir |