Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/51350
Título: | Engineering magnetically responsive tropoelastin spongy-like hydrogels for soft tissue regeneration |
Autor(es): | Pesqueira, Tamagno Almeida, Raquel Carvalho Ferreira Costa Mithieux, Suzanne M. Babo, Pedro Miguel Sousa Franco, Albina Ribeiro Mendes, Bárbara B. Domingues, Rui Miguel Andrade Freitas, Paulo Reis, R. L. Gomes, Manuela E. Weiss, Anthony S. |
Palavras-chave: | Magnetic field Magnetic nanoparticles Spongy-like hydrogel Tropoelastin |
Data: | 26-Jan-2018 |
Editora: | Royal Society of Chemistry |
Revista: | Journal of Materials Chemistry B |
Citação: | Pesqueira T., Costa-Almeida R., Mithieux S. M., Babo P. S., Franco A. R., Mendes B. B., Domingues R. M. A., Freitas P., Reis R. L., Gomes M. E., Weiss A. S. Engineering magnetically responsive tropoelastin spongy-like hydrogels for soft tissue regeneration, Journal Of Materials Chemistry B, doi:10.1039/C7TB02035J, 2018 |
Resumo(s): | Magnetic biomaterials are a key focus in medical research. Tropoelastin is the soluble precursor of elastin and is a critical component of tissues requiring elasticity as part of their physiological function. By utilising the versatility of tropoelastin and the ability to tailor its properties, we developed a novel magnetic spongy-like hydrogel based on tropoelastin doped with magnetic properties by in situ precipitation method. The presence of magnetic nanoparticles altered the secondary structure of tropoelastin. Bioengineered tropoelastin-based magnetic spongy-like hydrogels displayed a homogenous distribution of magnetic nanoparticles throughout the tropoelastin network and quick magnetic responsiveness to an applied external magnetic field. Morphologically, in the presence of magnetic nanoparticles, hydrated tropoelastin spongy-like hydrogels showed apparently smaller pore sizes and less swelling. Furthermore, in vitro biological studies using human tendon-derived cells revealed that magnetically responsive tropoelastin spongy-like hydrogels supported cell viability and enabled cell adhesion, spreading and migration into the interior of the spongy-like hydrogel up to two weeks. The bioengineered tropoelastin-based magnetic spongy-like hydrogel represents a novel class of hybrid biomaterial that can serve as a platform for soft tissue regeneration. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/51350 |
DOI: | 10.1039/C7TB02035J |
ISSN: | 2050-750X |
e-ISSN: | 2050-7518 |
Versão da editora: | http://pubs.rsc.org/en/content/articlelanding/2018/tb/c7tb02035j#!divAbstract |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19311-Pesqueira et al 2018_J Mater Chemistry B.pdf Acesso restrito! | 2,03 MB | Adobe PDF | Ver/Abrir |