Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies

doi:10.1016/j.ejmech.2005.10.016

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/5168

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Campo DC	Valor	Idioma
dc.contributor.author	Oliveira, Ana M. A. G.	-
dc.contributor.author	Campos, Ana M. F. Oliveira	-
dc.contributor.author	Raposo, M. Manuela M.	-
dc.contributor.author	Machado, António E. H.	-
dc.contributor.author	Puapairoj, Prapawadee	-
dc.contributor.author	Pedro, Madalena	-
dc.contributor.author	Nascimento, Maria São José	-
dc.contributor.author	Portela, César	-
dc.contributor.author	Afonso, Carlos A. M.	-
dc.contributor.author	Pinto, Madalena	-
dc.date.accessioned	2006-06-26T15:34:15Z	-
dc.date.available	2006-06-26T15:34:15Z	-
dc.date.issued	2006-03	-
dc.identifier.citation	Oliveira, A. M. A. G., Raposo, M. M. M., Oliveira-Campos, A. M. F., Machado, A. E. H., Puapairoj, P., Pedro, M., . . . Pinto, M. (2006). Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies. European Journal of Medicinal Chemistry, 41(3), 367-372. doi: https://doi.org/10.1016/j.ejmech.2005.10.016	eng
dc.identifier.issn	0223-5434	eng
dc.identifier.uri	https://hdl.handle.net/1822/5168	-
dc.description.abstract	Eight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins) is presented as well as the results of the ab initio calculations to find the parameters that relate the structure with the antitumor activity. This work provides supplementary information that could allow the development of new psoralen analogues with this type of biological activity.	eng
dc.description.sponsorship	For financial support from Fundação para a Ciência e Tecnologia, Portugal (I&D no. 226/9 and to CQ-UM), POCTI and FEDER; Ph.D. grants from FCT: Ana M.A.G. Oliveira (PRAXIS XXI/BD/19707/99), Madalena Pedro (SFRH/BD/1456/2000) and César Portela (SFRH/BD/3036/2000). For financial support and research grants to FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais) and CNPq (Conselho Nacional do Desenvolvimento Científico e Tecnológico, Brazil). The authors thank National Cancer Institute, Bethesda, MD (USA) for kindly providing the tumor cell lines and Elisa Pinto for obtaining 1H-NMR and 13C-NMR spectra and elemental analyses.	por
dc.description.sponsorship	POCTI.	por
dc.language.iso	eng	eng
dc.publisher	Elsevier 1	eng
dc.relation	info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F1456%2F2000/PT	-
dc.relation	info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F3036%2F2000/PT	-
dc.rights	openAccess	eng
dc.subject	Furocoumarins	eng
dc.subject	Benzopsoralens	eng
dc.subject	Antitumor	eng
dc.subject	Computational studies	eng
dc.title	Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies	eng
dc.type	article	por
dc.peerreviewed	yes	eng
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0223523405003090	eng
sdum.number	3	eng
sdum.pagination	367-372	eng
sdum.publicationstatus	published	eng
sdum.volume	41	eng
oaire.citationStartPage	367	por
oaire.citationEndPage	372	por
oaire.citationIssue	3	por
oaire.citationVolume	41	por
dc.identifier.doi	10.1016/j.ejmech.2005.10.016	por
dc.identifier.pmid	16439037	por
dc.subject.wos	Science & Technology	por
sdum.journal	European Journal of Medical Chemistry	por
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