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https://hdl.handle.net/1822/51989
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Noro, Jennifer Martins | por |
dc.contributor.author | Maciel, J. | por |
dc.contributor.author | Duarte, D. | por |
dc.contributor.author | Olival, A. C. D. | por |
dc.contributor.author | Baptista, C. | por |
dc.contributor.author | Silva, A. C. D. | por |
dc.contributor.author | Alves, Maria José Chão | por |
dc.contributor.author | Kong, Thoo Lin | por |
dc.date.accessioned | 2018-03-09T16:45:37Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Noro J, Maciel J, Duarte D, Olival ACD, Baptista C, et al. (2015) Evaluation of New Naphthalimides as Potential Anticancer Agents against Breast Cancer MCF-7, Pancreatic Cancer BxPC-3 and Colon Cancer HCT-15 Cell Lines. Organic Chem Curr Res 4: 144. doi:10.4172/21610401.1000144 | por |
dc.identifier.issn | 2161-0401 | por |
dc.identifier.uri | https://hdl.handle.net/1822/51989 | - |
dc.description.abstract | New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functionalities were synthesized and tested against a panel of breast cancer MCF-7, colon cancer HCT-15 and pancreatic cancer BxPC-3 cell lines. Generally structures with shorter alkyl chains were more active, with the one exception of the amide containing a p-nitrophenyl group. GI50 values (µM) were determined for the most active compounds. Three compounds exhibited GI50 values below 5 µM, two with MCF-7 cells, and one other with HCT-15. Compounds with different functionalities demonstrated cell line specificity: the MCF-7 cell line was more sensitive to an urea derivative (6f), the growth of HCT15 cells were most affected by a triazole (9d), while the BxPC-3 cell line was inhibited in a higher extend by a guanidine (4a). | por |
dc.description.sponsorship | The research leading to these results has received funding from Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Educação e Ciência (MEC) cofounded by FEDER, partnership agreement PT2020, through the Research Unit No. 4293. Joana Maciel was supported by a post-doctoral fellowship from the FCT project grant No. PTDC/BIA-MIC/118644/2010. Catarina Baptista is supported by a fellowship from the European Community’s Seventh Framework Programme under grant agreements No. 603240 (project NMTrypI). Jennifer Noro grant was supported by FCT project ref PTDC/QEQ-MED/1671/2012. We thank FCT and FEDER for funding NMR spectrometer Bruker Avance III 400 as part of the National NMR Network, and the EPSRC UK National Mass Spectrometry Facility (NMSF) at Swansea University for all the HR analyses. | por |
dc.language.iso | eng | por |
dc.publisher | OMICS International | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/118644/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/118644/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/126927/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/126927/PT | por |
dc.rights | closedAccess | por |
dc.subject | Toxicity | por |
dc.subject | Tetrabromide | por |
dc.subject | Naphthalimide | por |
dc.subject | Isocyanate | por |
dc.subject | Membrane permeabilization | por |
dc.title | Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT- 15 cell lines | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationVolume | 4:3 | por |
dc.identifier.doi | 10.4172/2161-0401.1000144 | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
sdum.journal | Organic Chemistry: Current Research | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Organic Chemistry. current research.pdf Acesso restrito! | 985,2 kB | Adobe PDF | Ver/Abrir |