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TitleDevelopment of magnetically active scaffolds for bone regeneration
Author(s)Díaz, E.
Valle, M. B.
Ribeiro, S.
Lanceros-Méndez, S.
Barandiarán, J. M.
Fe-doped hydroxyapatite
Poly (L-lactide)
Issue date2018
PublisherMDPI AG
CitationDíaz, E.; Valle, M.B.; Ribeiro, S.; Lanceros-Mendez, S.; Barandiarán, J.M. Development of Magnetically Active Scaffolds for Bone Regeneration. Nanomaterials 2018, 8, 678.
Abstract(s)This work reports on the synthesis, with the thermally induced phase separation (TIPS) technique, of poly (L-lactide) (PLLA) scaffolds containing Fe-doped hydroxyapatite (FeHA) particles for bone regeneration. Magnetization curves and X-ray diffraction indicate two magnetic particle phases: FeHA and magnetite Fe3O4. Magnetic nanoparticles (MNPs) are approximately 30 ± 5 nm in width and 125 ± 25 nm in length, and show typical ferromagnetic properties, including coercivity and rapid saturation magnetization. Scanning electron microscopy (SEM) images of the magnetic scaffolds reveal their complex morphology changes with MNP concentration. Similarly, at compositions of approximately 20% MNPs, the phase separation changes, passing from solid–liquid to liquid–liquid as revealed by the hill-like structures, with low peaks that give the walls in the SEM images a surface pattern of micro-ruggedness typical of nucleation mechanisms and growth. In vitro degradation experiments, carried out for more than 28 weeks, demonstrated that the MNPs delay the scaffold degradation process. Cytotoxicity is appreciated for FeHA content above 20%.
AccessOpen access
Appears in Collections:CDF - FCD - Artigos/Papers (with refereeing)
DBio - Artigos/Papers

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