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https://hdl.handle.net/1822/5746| Título: | Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer |
| Autor(es): | Costa, Sandra Maria Araújo da Pinto, Daniela Pereira, Deolinda Vasconcelos, André Lopes, Carlos Afonso Osório, Teresa Lopes, Carlos Medeiros, Rui |
| Palavras-chave: | XPD DNA repair NER Ovarian cancer Polymorphisms |
| Data: | 2007 |
| Editora: | Elsevier |
| Revista: | Cancer Letters |
| Citação: | "Cancer letters". ISSN 0304-3835. (in Press). |
| Resumo(s): | The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (ORZ2.46 95% CI 1.20–5.06; PZ0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (ORZ3.40 95% CI 1.61–7.15; PZ0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/5746 |
| DOI: | 10.1016/j.canlet.2006.03.014 |
| ISSN: | 0304-3835 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| cl06_costas.pdf | 170,4 kB | Adobe PDF | Ver/Abrir |
