Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/57948

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dc.contributor.authorSoares, Ana Rosapor
dc.contributor.authorEsteves, Madalenapor
dc.contributor.authorMoreira, Pedro Miguel Silvapor
dc.contributor.authorCunha, Ana Margaridapor
dc.contributor.authorGuimarães, Marco Rafael Machadopor
dc.contributor.authorCarvalho, Miguel Murteirapor
dc.contributor.authorRaposo-Lima, Catarinapor
dc.contributor.authorMorgado, Pedropor
dc.contributor.authorCarvalho, Ana Raquel Franky Gomespor
dc.contributor.authorCoimbra, Bárbara Guimarães Salazarpor
dc.contributor.authorMelo, Antóniopor
dc.contributor.authorRodrigues, Ana Joãopor
dc.contributor.authorSalgado, A. J.por
dc.contributor.authorPêgo, José M.por
dc.contributor.authorCerqueira, João Josépor
dc.contributor.authorCosta, Patrício Soarespor
dc.contributor.authorSousa, Nunopor
dc.contributor.authorAlmeida, Armandopor
dc.contributor.authorLeite-Almeida, Hugopor
dc.date.accessioned2019-01-09T10:25:44Z-
dc.date.available2019-01-09T10:25:44Z-
dc.date.issued2018-12-05-
dc.identifier.citationSoares, A. R., Esteves, M., Moreira, P. S., Cunha, A. M., Guimarães, M. R., Carvalho, M. M., ... & Melo, A. (2018). Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats. Scientific reports, 8(1), 17666por
dc.identifier.issn2045-2322por
dc.identifier.urihttps://hdl.handle.net/1822/57948-
dc.description.abstractImpulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the influence of modulating effects. We designed the present study to investigate, in a cohort of significant size (188 rats), the impact of four specific parameters, namely sex, age, strain and phase of estrous cycle, using the variable delay-to-signal (VDS) task. This cohort included (i) control animals from previous experiments; (ii) animals specifically raised for this study; and (iii) animals previously used for breeding purposes. Aging was associated with a general decrease in action impulsivity and an increase in delay tolerance. Females generally performed more impulsive actions than males but no differences were observed regarding delay intolerance. In terms of estrous cycle, no differences in impulsive behavior were observed and regarding strain, Wistar Han animals were, in general, more impulsive than Sprague-Dawley. In addition to further confirming, in a substantial study cohort, the decrease in impulsivity with age, we have demonstrated that both the strain and sex influences modulate different aspects of impulsive behavior manifestations.por
dc.description.sponsorshipFEDER funds, through the Competitiveness Factors Operational Programme (COMPETE) and the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement as well as national funds, through the Foundation for Science and Technology (FCT) [projects POCI-01–0145-FEDER-007038, NORTE-01-0145-FEDER-000013, NORTE-01-0145-FEDER-000023 and PTDC/NEU-SCC/5301/2014]. Researchers were supported by FCT [grant numbers SFRH/BD/52291/2013 to ME and PD/BD/114117/2015 to MRG via Inter-University Doctoral Programme in Ageing and Chronic Disease, PhDOC; PDE/BDE/113601/2015 to PSM via PhD Program in Health Sciences (Applied) and Phd-iHES; SFRH/BD/109111/2015 to AMC; SFRH/BD/51061/2010 to MMC; SFRH/SINTD/60126/2009 to AM; SFRH/BD/98675/2013 to BC; IF/00883/2013 to AJR; IF/00111/2013 to AJS; SFRH/BPD/80118/2011 to HLA]por
dc.language.isoengpor
dc.publisherNature Researchpor
dc.rightsopenAccesspor
dc.titleTrait determinants of impulsive behavior: a comprehensive analysis of 188 ratspor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-018-35537-7por
oaire.citationStartPage17666por
oaire.citationIssue1por
oaire.citationVolume8por
dc.identifier.eissn2045-2322-
dc.identifier.doi10.1038/s41598-018-35537-7por
dc.identifier.pmid30518850por
dc.subject.fosCiências Médicas::Medicina Básicapor
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersionpor
dc.subject.wosScience & Technologypor
sdum.journalScientific Reportspor
Aparece nas coleções:ICVS - Artigos em revistas internacionais / Papers in international journals

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