Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58010
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Pinho, Eva Patrícia Paiva Santos | por |
dc.contributor.author | Calhelha, Ricardo C. | por |
dc.contributor.author | Ferreira, Isabel C. F. R. | por |
dc.contributor.author | Soares, Graça M. B. | por |
dc.date.accessioned | 2019-01-10T14:20:05Z | - |
dc.date.available | 2019-01-10T14:20:05Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1042-7147 | por |
dc.identifier.uri | https://hdl.handle.net/1822/58010 | - |
dc.description.abstract | Infection is one of the major risk factors for the development of chronic wounds.Antimicrobial wound dressing has been pointed out as a viable option for the preven-tion and treatment of wound infections. Thus, we developed a composite materialbased on cotton textile substrates functionalized with cyclodextrin‐hydroxypropylmethyl cellulose‐based hydrogel. The composites' ability to encapsulate and releasegallic acid (antimicrobial phenolic acid) was evaluated, as well as their mechanicalproperties and antimicrobial and anti‐inflammatory capacity. All composites were ableto retain gallic acid in their structure, with similar loading profile. The presence of gal-lic acid on composites was confirmed by FTIR and TGA. Composites storage moduliwas reduced by the presence of gallic acid. The results suggest a straight relationbetween the swelling ability and gallic acid drug delivery profile. The drug deliverymechanism, of the developed composites, was mainly controlled by Fickian diffusion,based on the experimental data fitting to the Peppas‐Sahlin model. Gallic acid antimi-crobial and anti‐inflammatory properties were transferred to the composite materials.According to the results, the developed composites can be applied on the preventionor treatment of chronic wounds | por |
dc.description.sponsorship | This article is a result of the project TSSiPRO—NORTE‐01‐0145‐ FEDER‐000015—supported by the regional operational program NORTE 2020, under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund. The authors, also, acknowledge the Portuguese Foundation for Science and Technology (FCT) funding from the project UID/CTM/00264/2013 and UID/AGR/00690/2013 and FEDER funds through the COMPETE 2020–Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI‐01‐0145‐FEDER‐007136. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147331/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147451/PT | por |
dc.rights | openAccess | por |
dc.subject | Anti‐inflammatory | por |
dc.subject | Antimicrobial | por |
dc.subject | Chronic wound | por |
dc.subject | Composite wound dressin | por |
dc.subject | composite wound dressing | por |
dc.subject | gallic acid | por |
dc.subject | infection | por |
dc.title | Cotton-hydrogel composite for improved wound healing: antimicrobial activity and anti-inflammatory evaluation - part 2 | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 863 | por |
oaire.citationEndPage | 871 | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 30 | por |
dc.identifier.doi | 10.1002/pat.4519 | por |
dc.subject.fos | Engenharia e Tecnologia::Engenharia dos Materiais | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Polymers for Advanced Technologies | por |
Aparece nas coleções: | DET/2C2T - Artigos em revistas internacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Pinho_et_al-2018-Polymers_for_Advanced_Technologies.pdf | 608,98 kB | Adobe PDF | Ver/Abrir |