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https://hdl.handle.net/1822/58059
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Campo DC | Valor | Idioma |
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dc.contributor.author | Mesquita, Inês Morais | por |
dc.contributor.author | Ferreira, Carolina | por |
dc.contributor.author | Barbosa, Ana Margarida | por |
dc.contributor.author | Ferreira, Catarina Machado | por |
dc.contributor.author | Moreira, Diana | por |
dc.contributor.author | Carvalho, Agostinho | por |
dc.contributor.author | Cunha, Cristina | por |
dc.contributor.author | Rodrigues, Fernando | por |
dc.contributor.author | Dinis-Oliveira, Ricardo Jorge | por |
dc.contributor.author | Estaquier, Jérôme | por |
dc.contributor.author | Castro, António G. | por |
dc.contributor.author | Torrado, Egídio | por |
dc.contributor.author | Silvestre, Ricardo Jorge Leal | por |
dc.date.accessioned | 2019-01-11T12:17:37Z | - |
dc.date.available | 2020-01-01T07:00:38Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | Mesquita, I., Ferreira, C., Barbosa, A. M., Ferreira, C. M., et. al. (2018). The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis. Cytokine, 112, 16-20 | por |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | https://hdl.handle.net/1822/58059 | - |
dc.description.abstract | Leishmaniasis is a vector-borne disease caused by protozoan parasites from the genus Leishmania. The most severe form of disease is visceral leishmaniasis (VL), which is fatal if left untreated. It has been demonstrated that interleukin (IL)-10, is associated with disease progression and susceptibility. In this work, we took advantage of a transgenic mouse model that expresses high levels of IL-10 upon zinc sulfate administration (pMT-10). We addressed the role of IL-10 during the initial stages of L. donovani infection by analyzing the parasite burden in the spleen and liver of the infected pMT-10 and WT mice as well as the histopathological alterations upon IL-10 induction. Furthermore, the profile of cytokines expressed by T cells was assessed. Our results demonstrate that an increase in IL-10 production has an impact early but not later after infection. This specific temporal role for IL-10-mediated susceptibility to VL is of interest. | por |
dc.description.sponsorship | Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013) and the Fundação para a Ciência e Tecnologia (FCT) (contracts SFRH/BD/120127/2016 to IM, PD/BDE/127830/2016 to CF, SFRH/BD/120371/2016 to AMB, IF/01147/2013 to RDO, IF/01390/2014 to ET, IF/00735/2014 to AC, SFRH/BPD/96176/2013 to CC and IF/00021/2014 to RS), and Infect-Era (project INLEISH). JE also thanks the Canada Research Chair program for financial assistance | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F120127%2F2016/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBDE%2F127830%2F2016/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F120371%2F2016/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01147%2F2013%2FCP1154%2FCT0014/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01390%2F2014%2FCP1212%2FCT0010/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00735%2F2014%2FCP1212%2FCT0001/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F96176%2F2013/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00021%2F2014%2FCP1212%2FCT0009/PT | - |
dc.rights | openAccess | por |
dc.subject | Visceral leishmaniasis | por |
dc.subject | IL-10 | por |
dc.subject | Multifunctional CD4+ T cells | por |
dc.subject | IFN-γ | por |
dc.subject | IFN-gamma | por |
dc.title | The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1043466618302874 | por |
oaire.citationStartPage | 16 | por |
oaire.citationEndPage | 20 | por |
oaire.citationVolume | 112 | por |
dc.identifier.eissn | 1096-0023 | - |
dc.identifier.doi | 10.1016/j.cyto.2018.07.001 | por |
dc.identifier.pmid | 30017388 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Cytokine | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis.pdf | 942,37 kB | Adobe PDF | Ver/Abrir |