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https://hdl.handle.net/1822/58202
Título: | Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma |
Autor(es): | Moron, Roberson A. Jacob, Carlos Eduardo Bresciani, Claudio José Caldas Simões, Kleber Alves, Venâncio Avancini Ferreira Irya, Kyoshi Gama-Rodrigues, Joaquim Cecconello, Ivan Longatto, Adhemar Zilberstein, Bruno |
Palavras-chave: | gastric cancer p21(ras) p53 p21(waf1/cip1) p27(kip1) p16(ink4a) |
Data: | Mar-2018 |
Editora: | Spandidos Publications |
Revista: | Molecular and Clinical Oncology |
Citação: | Moron, R. A., Jacob, C. E., Bresciani, C. J. C., Simões, K., Alves, V. A. F., Irya, K., ... & Zilberstein, B. (2018). Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma. Molecular and Clinical Oncology, 8(3), 477-482. |
Resumo(s): | The aim of the present study was to determine the clinical significance of p53 and p21ras p21wafl, p27kip1 and p16ink4a expression in cases of early gastric cancer. A total of 81 patients who had undergone gastrectomy with D2 lymphadenectomy between 1971 and 2004 were retrospectively investigated. The immunohistochemical expression of p21ras, p53, p21waf1/cip1, p27kip1 and p16ink4a in the tissues was evaluated. In normal, metaplastic and tumoral mucosa, p53 was positive in 53, 87.3, and 87.1% of the cases, respectively. In the same tissues, p21ras was positivE in 85.3, 86 and 96.8%, respectively. Positivity FOR p16ink4a was DETECTED IN 46.3, 91.1 and 86% OF THE CASES, respectively, WHEREAS p27kip1 WAS positiVE IN 60, 94.7 and 95.3%, and p21wafl/cip1 WAS positivE IN 32.4, 72.7 and 71.4% OF THE CASES, respectively. All THE tumors WERE positive for p53. Tumors with lymph node invasion presented WITH OVERexpression (+4) of p53 in 47% of the cases VS. 17% OF patients who DID not HAVE lymph node involvement. THEREFORE, higher expression of p53, p21ras and p21wafl/cip1 IN the tumor exhibited a statistically significant association with lymph node involvement. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58202 |
DOI: | 10.3892/mco.2017.1545 |
ISSN: | 2049-9450 |
e-ISSN: | 2049-9469 |
Versão da editora: | https://www.spandidos-publications.com/mco/8/3/477 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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moron 2018.pdf | 300,26 kB | Adobe PDF | Ver/Abrir |